Search Results

Overview

Uniprot ID	P49312
Protein Name	Heterogeneous nuclear ribonucleoprotein A1
Gene Name	Hnrnpa1
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
298	GGGQYFAKPRNQGGY
3	*****MSKSESPKEP

Function

Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins

Protein Sequence

10 MSKSESPKEP 20 EQLRKLFIGG 30 LSFETTDESL 40 RSHFEQWGTL 50 TDCVVMRDPN 60 TKRSRGFGFV 70 TYATVEEVDA 80 AMNARPHKVD 90 GRVVEPKRAV 100 SREDSQRPGA 110 HLTVKKIFVG 120 GIKEDTEEHH 130 LRDYFEQYGK 140 IEVIEIMTDR 150 GSGKKRGFAF 160 VTFDDHDSVD 170 KIVIQKYHTV 180 NGHNCEVRKA 190 LSKQEMASAS 200 SSQRGRSGSG 210 NFGGGRGGGF 220 GGNDNFGRGG 230 NFSGRGGFGG 240 SRGGGGYGGS 250 GDGYNGFGND 260 GSNFGGGGSY 270 NDFGNYNNQS 280 SNFGPMKGGN 290 FGGRSSGPYG 300 GGGQYFAKPR 310 NQGGYGGSSS 320 SSSYGSGRRF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0071013	catalytic step 2 spliceosome
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:1990826	nucleoplasmic periphery of the nuclear pore complex
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:1990904	ribonucleoprotein complex
Cellular Component	GO:0005681	spliceosomal complex
Cellular Component	GO:0045202	synapse
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:1990814	DNA/DNA annealing activity
Molecular Function	GO:0098505	G-rich strand telomeric DNA binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0035198	miRNA binding
Molecular Function	GO:0003730	mRNA 3'-UTR binding
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0036002	pre-mRNA binding
Molecular Function	GO:0019904	protein domain specific binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0033592	RNA strand annealing activity
Molecular Function	GO:1990825	sequence-specific mRNA binding
Molecular Function	GO:0003697	single-stranded DNA binding
Molecular Function	GO:0003727	single-stranded RNA binding
Molecular Function	GO:0061752	telomeric repeat-containing RNA binding
Biological Process	GO:0000380	alternative mRNA splicing, via spliceosome
Biological Process	GO:0042149	cellular response to glucose starvation
Biological Process	GO:0035865	cellular response to potassium ion
Biological Process	GO:1903936	cellular response to sodium arsenite
Biological Process	GO:0051170	import into nucleus
Biological Process	GO:0000398	mRNA splicing, via spliceosome
Biological Process	GO:0051028	mRNA transport
Biological Process	GO:0032211	negative regulation of telomere maintenance via telomerase
Biological Process	GO:0051168	nuclear export
Biological Process	GO:0045760	positive regulation of action potential
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
Biological Process	GO:0008380	RNA splicing

Reference

[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.

[2] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.