Search Results

Overview

Uniprot IDP49327
Protein NameFatty acid synthase
Gene NameFASN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1065 DPATHRQKLYTLQDK
1072 KLYTLQDKAQVADVV
1151 LVQALQTKVTQQGLK
1158 KVTQQGLKMVVPGLD
1239 VENMPSLKMKVVEVL
1241 NMPSLKMKVVEVLAG
1393 LRLVGLKKSFYGSTL
1582 DIMLATGKLSPDAIP
1704 TTVGSAEKRAYLQAR
1847 FRYMAQGKHIGKVVV
1851 AQGKHIGKVVVQVLA
1866 EEPEAVLKGAKPKLM
1871 VLKGAKPKLMSAISK
1878 KLMSAISKTFCPAHK
1911 LIQRGVQKLVLTSRS
1927 IRTGYQAKQVRRWRR
2186 VRQLTLRKLQELSSK
2193 KLQELSSKADEASEL
2206 ELACPTPKEDGLAQQ
235 VVAVLLTKKSLARRV
2391 LEALLPLKGLEERVA
2406 AAVDLIIKSHQGLDR
2426 AARSFYYKLRAAEQY
2436 AAEQYTPKAKYHGNV
2438 EQYTPKAKYHGNVML
2449 NVMLLRAKTGGAYGE
2471 LSQVCDGKVSVHVIE
326 PLLIGSTKSNMGHPE
41 TDDDRRWKAGLYGLP
436 RTPEAVQKLLEQGLR
528 LRSDEAVKPFGLKVS
667 EFVEQLRKEGVFAKE
673 RKEGVFAKEVRTGGM
70 SFFGVHPKQAHTMDP

Function

Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain

Protein Sequence

10 MEEVVIAGMS 20 GKLPESENLQ 30 EFWDNLIGGV 40 DMVTDDDRRW 50 KAGLYGLPRR 60 SGKLKDLSRF 70 DASFFGVHPK 80 QAHTMDPQLR 90 LLLEVTYEAI 100 VDGGINPDSL 110 RGTHTGVWVG 120 VSGSETSEAL 130 SRDPETLVGY 140 SMVGCQRAMM 150 ANRLSFFFDF 160 RGPSIALDTA 170 CSSSLMALQN 180 AYQAIHSGQC 190 PAAIVGGINV 200 LLKPNTSVQF 210 LRLGMLSPEG 220 TCKAFDTAGN 230 GYCRSEGVVA 240 VLLTKKSLAR 250 RVYATILNAG 260 TNTDGFKEQG 270 VTFPSGDIQE 280 QLIRSLYQSA 290 GVAPESFEYI 300 EAHGTGTKVG 310 DPQELNGITR 320 ALCATRQEPL 330 LIGSTKSNMG 340 HPEPASGLAA 350 LAKVLLSLEH 360 GLWAPNLHFH 370 SPNPEIPALL 380 DGRLQVVDQP 390 LPVRGGNVGI 400 NSFGFGGSNV 410 HIILRPNTQP 420 PPAPAPHATL 430 PRLLRASGRT 440 PEAVQKLLEQ 450 GLRHSQDLAF 460 LSMLNDIAAV 470 PATAMPFRGY 480 AVLGGERGGP 490 EVQQVPAGER 500 PLWFICSGMG 510 TQWRGMGLSL 520 MRLDRFRDSI 530 LRSDEAVKPF 540 GLKVSQLLLS 550 TDESTFDDIV 560 HSFVSLTAIQ 570 IGLIDLLSCM 580 GLRPDGIVGH 590 SLGEVACGYA 600 DGCLSQEEAV 610 LAAYWRGQCI 620 KEAHLPPGAM 630 AAVGLSWEEC 640 KQRCPPGVVP 650 ACHNSKDTVT 660 ISGPQAPVFE 670 FVEQLRKEGV 680 FAKEVRTGGM 690 AFHSYFMEAI 700 APPLLQELKK 710 VIREPKPRSA 720 RWLSTSIPEA 730 QWHSSLARTS 740 SAEYNVNNLV 750 SPVLFQEALW 760 HVPEHAVVLE 770 IAPHALLQAV 780 LKRGLKPSCT 790 IIPLMKKDHR 800 DNLEFFLAGI 810 GRLHLSGIDA 820 NPNALFPPVE 830 FPAPRGTPLI 840 SPLIKWDHSL 850 AWDVPAAEDF 860 PNGSGSPSAA 870 IYNIDTSSES 880 PDHYLVDHTL 890 DGRVLFPATG 900 YLSIVWKTLA 910 RALGLGVEQL 920 PVVFEDVVLH 930 QATILPKTGT 940 VSLEVRLLEA 950 SRAFEVSENG 960 NLVVSGKVYQ 970 WDDPDPRLFD 980 HPESPTPNPT 990 EPLFLAQAEV 1000 YKELRLRGYD 1010 YGPHFQGILE 1020 ASLEGDSGRL 1030 LWKDNWVSFM 1040 DTMLQMSILG 1050 SAKHGLYLPT 1060 RVTAIHIDPA 1070 THRQKLYTLQ 1080 DKAQVADVVV 1090 SRWLRVTVAG 1100 GVHISGLHTE 1110 SAPRRQQEQQ 1120 VPILEKFCFT 1130 PHTEEGCLSE 1140 RAALQEELQL 1150 CKGLVQALQT 1160 KVTQQGLKMV 1170 VPGLDGAQIP 1180 RDPSQQELPR 1190 LLSAACRLQL 1200 NGNLQLELAQ 1210 VLAQERPKLP 1220 EDPLLSGLLD 1230 SPALKACLDT 1240 AVENMPSLKM 1250 KVVEVLAGHG 1260 HLYSRIPGLL 1270 SPHPLLQLSY 1280 TATDRHPQAL 1290 EAAQAELQQH 1300 DVAQGQWDPA 1310 DPAPSALGSA 1320 DLLVCNCAVA 1330 ALGDPASALS 1340 NMVAALREGG 1350 FLLLHTLLRG 1360 HPLGDIVAFL 1370 TSTEPQYGQG 1380 ILSQDAWESL 1390 FSRVSLRLVG 1400 LKKSFYGSTL 1410 FLCRRPTPQD 1420 SPIFLPVDDT 1430 SFRWVESLKG 1440 ILADEDSSRP 1450 VWLKAINCAT 1460 SGVVGLVNCL 1470 RREPGGNRLR 1480 CVLLSNLSST 1490 SHVPEVDPGS 1500 AELQKVLQGD 1510 LVMNVYRDGA 1520 WGAFRHFLLE 1530 EDKPEEPTAH 1540 AFVSTLTRGD 1550 LSSIRWVCSS 1560 LRHAQPTCPG 1570 AQLCTVYYAS 1580 LNFRDIMLAT 1590 GKLSPDAIPG 1600 KWTSQDSLLG 1610 MEFSGRDASG 1620 KRVMGLVPAK 1630 GLATSVLLSP 1640 DFLWDVPSNW 1650 TLEEAASVPV 1660 VYSTAYYALV 1670 VRGRVRPGET 1680 LLIHSGSGGV 1690 GQAAIAIALS 1700 LGCRVFTTVG 1710 SAEKRAYLQA 1720 RFPQLDSTSF 1730 ANSRDTSFEQ 1740 HVLWHTGGKG 1750 VDLVLNSLAE 1760 EKLQASVRCL 1770 ATHGRFLEIG 1780 KFDLSQNHPL 1790 GMAIFLKNVT 1800 FHGVLLDAFF 1810 NESSADWREV 1820 WALVQAGIRD 1830 GVVRPLKCTV 1840 FHGAQVEDAF 1850 RYMAQGKHIG 1860 KVVVQVLAEE 1870 PEAVLKGAKP 1880 KLMSAISKTF 1890 CPAHKSYIIA 1900 GGLGGFGLEL 1910 AQWLIQRGVQ 1920 KLVLTSRSGI 1930 RTGYQAKQVR 1940 RWRRQGVQVQ 1950 VSTSNISSLE 1960 GARGLIAEAA 1970 QLGPVGGVFN 1980 LAVVLRDGLL 1990 ENQTPEFFQD 2000 VCKPKYSGTL 2010 NLDRVTREAC 2020 PELDYFVVFS 2030 SVSCGRGNAG 2040 QSNYGFANSA 2050 MERICEKRRH 2060 EGLPGLAVQW 2070 GAIGDVGILV 2080 ETMSTNDTIV 2090 SGTLPQRMAS 2100 CLEVLDLFLN 2110 QPHMVLSSFV 2120 LAEKAAAYRD 2130 RDSQRDLVEA 2140 VAHILGIRDL 2150 AAVNLDSSLA 2160 DLGLDSLMSV 2170 EVRQTLEREL 2180 NLVLSVREVR 2190 QLTLRKLQEL 2200 SSKADEASEL 2210 ACPTPKEDGL 2220 AQQQTQLNLR 2230 SLLVNPEGPT 2240 LMRLNSVQSS 2250 ERPLFLVHPI 2260 EGSTTVFHSL 2270 ASRLSIPTYG 2280 LQCTRAAPLD 2290 SIHSLAAYYI 2300 DCIRQVQPEG 2310 PYRVAGYSYG 2320 ACVAFEMCSQ 2330 LQAQQSPAPT 2340 HNSLFLFDGS 2350 PTYVLAYTQS 2360 YRAKLTPGCE 2370 AEAETEAICF 2380 FVQQFTDMEH 2390 NRVLEALLPL 2400 KGLEERVAAA 2410 VDLIIKSHQG 2420 LDRQELSFAA 2430 RSFYYKLRAA 2440 EQYTPKAKYH 2450 GNVMLLRAKT 2460 GGAYGEDLGA 2470 DYNLSQVCDG 2480 KVSVHVIEGD 2490 HRTLLEGSGL 2500 ESIISIIHSS 2510 LAEPRVSVRE G

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0031177 phosphopantetheine binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006084 acetyl-CoA metabolic process
Biological Process GO:0008611 ether lipid biosynthetic process
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0006631 fatty acid metabolic process
Biological Process GO:0046949 fatty-acyl-CoA biosynthetic process
Biological Process GO:0044788 host-mediated perturbation of viral process
Biological Process GO:0030879 mammary gland development
Biological Process GO:0030224 monocyte differentiation
Biological Process GO:0030223 neutrophil differentiation
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0007584 response to nutrient
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0042587 glycogen granule
Cellular Component GO:0042470 melanosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0019171 (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
Molecular Function GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
Molecular Function GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
Molecular Function GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity
Molecular Function GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0141148 enoyl-[acyl-carrier-protein] reductase (NADPH) activity
Molecular Function GO:0004312 fatty acid synthase activity
Molecular Function GO:0016297 fatty acyl-[ACP] hydrolase activity

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.