Search Results

Overview

Uniprot IDP49411
Protein NameElongation factor Tu, mitochondrial
Gene NameTUFM
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
237 RDPELGLKSVQKLLD
259 VPARDLEKPFLLPVE
289 LERGILKKGDECELL
364 AQVYILSKEEGGRHK
450 LAMTEEEKNIKWG**
82 TLTAAITKILAEGGG
91 LAEGGGAKFKKYEEI
94 GGGAKFKKYEEIDNA

Function

GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Participates in mitochondrial translation (By similarity). Also plays a role in the regulation of autophagy and innate immunity (PubMed:22749352, PubMed:28407488). Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway (PubMed:28407488). In turn, inhibits RLR-mediated type I interferon while promoting autophagy (PubMed:22749352)

Protein Sequence

10 MTTMAAATLL 20 RATPHFSGLA 30 AGRTFLLQGL 40 LRLLKAPALP 50 LLCRGLAVEA 60 KKTYVRDKPH 70 VNVGTIGHVD 80 HGKTTLTAAI 90 TKILAEGGGA 100 KFKKYEEIDN 110 APEERARGIT 120 INAAHVEYST 130 AARHYAHTDC 140 PGHADYVKNM 150 ITGTAPLDGC 160 ILVVAANDGP 170 MPQTREHLLL 180 ARQIGVEHVV 190 VYVNKADAVQ 200 DSEMVELVEL 210 EIRELLTEFG 220 YKGEETPVIV 230 GSALCALEGR 240 DPELGLKSVQ 250 KLLDAVDTYI 260 PVPARDLEKP 270 FLLPVEAVYS 280 VPGRGTVVTG 290 TLERGILKKG 300 DECELLGHSK 310 NIRTVVTGIE 320 MFHKSLERAE 330 AGDNLGALVR 340 GLKREDLRRG 350 LVMVKPGSIK 360 PHQKVEAQVY 370 ILSKEEGGRH 380 KPFVSHFMPV 390 MFSLTWDMAC 400 RIILPPEKEL 410 AMPGEDLKFN 420 LILRQPMILE 430 KGQRFTLRDG 440 NRTIGTGLVT 450 NTLAMTEEEK NIKWG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0042645 mitochondrial nucleoid
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003746 translation elongation factor activity
Biological Process GO:1902775 mitochondrial large ribosomal subunit assembly
Biological Process GO:0032543 mitochondrial translation
Biological Process GO:0070125 mitochondrial translational elongation
Biological Process GO:0006414 translational elongation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.