Search Results

Overview

Uniprot IDP49419
Protein NameAlpha-aminoadipic semialdehyde dehydrogenase
Gene NameALDH7A1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
109 WADIPAPKRGEIVRQ
124 IGDALREKIQVLGSL
352 EVVNRLKKAYAQIRV
389 LGAVEEAKKEGGTVV
390 GAVEEAKKEGGTVVY
439 ILYVFKFKNEEEVFA
452 FAWNNEVKQGLSSSI
462 LSSSIFTKDLGRIFR
500 GGAFGGEKHTGGGRE
528 TCTINYSKDLPLAQG
537 LPLAQGIKFQ*****
93 ADYEETVKKAREAWK

Function

Aldehyde dehydrogenase enzyme that mediates important protective effects (PubMed:16491085, PubMed:20207735, PubMed:20554659, PubMed:21338592, PubMed:25554827, PubMed:31302938, PubMed:31652343, PubMed:38604394, PubMed:40233740). Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes (PubMed:16491085, PubMed:20207735, PubMed:21338592, PubMed:40233740). Involved in cellular defense against hyperosmotic stress by metabolizing betaine aldehyde to betaine, an important cellular osmolyte and methyl donor (PubMed:20207735)

Protein Sequence

10 MWRLPRALCV 20 HAAKTSKLSG 30 PWSRPAAFMS 40 TLLINQPQYA 50 WLKELGLREE 60 NEGVYNGSWG 70 GRGEVITTYC 80 PANNEPIARV 90 RQASVADYEE 100 TVKKAREAWK 110 IWADIPAPKR 120 GEIVRQIGDA 130 LREKIQVLGS 140 LVSLEMGKIL 150 VEGVGEVQEY 160 VDICDYAVGL 170 SRMIGGPILP 180 SERSGHALIE 190 QWNPVGLVGI 200 ITAFNFPVAV 210 YGWNNAIAMI 220 CGNVCLWKGA 230 PTTSLISVAV 240 TKIIAKVLED 250 NKLPGAICSL 260 TCGGADIGTA 270 MAKDERVNLL 280 SFTGSTQVGK 290 QVGLMVQERF 300 GRSLLELGGN 310 NAIIAFEDAD 320 LSLVVPSALF 330 AAVGTAGQRC 340 TTARRLFIHE 350 SIHDEVVNRL 360 KKAYAQIRVG 370 NPWDPNVLYG 380 PLHTKQAVSM 390 FLGAVEEAKK 400 EGGTVVYGGK 410 VMDRPGNYVE 420 PTIVTGLGHD 430 ASIAHTETFA 440 PILYVFKFKN 450 EEEVFAWNNE 460 VKQGLSSSIF 470 TKDLGRIFRW 480 LGPKGSDCGI 490 VNVNIPTSGA 500 EIGGAFGGEK 510 HTGGGRESGS 520 DAWKQYMRRS 530 TCTINYSKDL PLAQGIKFQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0004029 aldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0008802 betaine-aldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0004043 L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
Molecular Function GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Biological Process GO:0006081 aldehyde metabolic process
Biological Process GO:0042426 choline catabolic process
Biological Process GO:0008333 endosome to lysosome transport
Biological Process GO:0097009 energy homeostasis
Biological Process GO:0019285 glycine betaine biosynthetic process from choline
Biological Process GO:0006895 Golgi to endosome transport
Biological Process GO:0019477 L-lysine catabolic process
Biological Process GO:0006554 lysine catabolic process
Biological Process GO:1905750 negative regulation of endosome to plasma membrane protein transport
Biological Process GO:0110076 negative regulation of ferroptosis
Biological Process GO:0042997 negative regulation of Golgi to plasma membrane protein transport
Biological Process GO:0048227 plasma membrane to endosome transport
Biological Process GO:0007605 sensory perception of sound

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.