Search Results
Overview
| Uniprot ID | P49441 |
|---|---|
| Protein Name | Inositol polyphosphate 1-phosphatase |
| Gene Name | INPP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 44 | KEGEKNKKFAVDFKT |
Function
Mg(2+)-dependent phosphatase that catalyzes the hydrolysis of the 1-position phosphate from inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate and participates in inositol phosphate metabolism
Protein Sequence
10
MSDILRELLC
20
VSEKAANIAR
30
ACRQQEALFQ
40
LLIEEKKEGE
50
KNKKFAVDFK
60
TLADVLVQEV
70
IKQNMENKFP
80
GLEKNIFGEE
90
SNEFTNDWGE
100
KITLRLCSTE
110
EETAELLSKV
120
LNGNKVASEA
130
LARVVHQDVA
140
FTDPTLDSTE
150
INVPQDILGI
160
WVDPIDSTYQ
170
YIKGSADIKS
180
NQGIFPCGLQ
190
CVTILIGVYD
200
IQTGVPLMGV
210
INQPFVSRDP
220
NTLRWKGQCY
230
WGLSYMGTNM
240
HSLQLTISRR
250
NGSETHTGNT
260
GSEAAFSPSF
270
SAVISTSEKE
280
TIKAALSRVC
290
GDRIFGAAGA
300
GYKSLCVVQG
310
LVDIYIFSED
320
TTFKWDSCAA
330
HAILRAMGGG
340
IVDLKECLER
350
NPETGLDLPQ
360
LVYHVENEGA
370
AGVDRWANKG
380
GLIAYRSRKR
390
LETFLSLLVQ
NLAPAETHT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0052829 | inositol-1,3,4-trisphosphate 1-phosphatase activity |
| Molecular Function | GO:0004441 | inositol-1,4-bisphosphate 1-phosphatase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006796 | phosphate-containing compound metabolic process |
| Biological Process | GO:0046854 | phosphatidylinositol phosphate biosynthetic process |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.