Search Results
Overview
| Uniprot ID | P49448 |
|---|---|
| Protein Name | Glutamate dehydrogenase 2, mitochondrial |
| Gene Name | GLUD2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 191 | AGVKINPKNYTENEL |
| 200 | YTENELEKITRRFTM |
| 390 | ATEKQLTKSNAPRVK |
| 527 | QIMHTAMKYNLGLDL |
Function
Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission
Protein Sequence
10
MYRYLAKALL
20
PSRAGPAALG
30
SAANHSAALL
40
GRGRGQPAAA
50
SQPGLALAAR
60
RHYSELVADR
70
EDDPNFFKMV
80
EGFFDRGASI
90
VEDKLVKDLR
100
TQESEEQKRN
110
RVRGILRIIK
120
PCNHVLSLSF
130
PIRRDDGSWE
140
VIEGYRAQHS
150
QHRTPCKGGI
160
RYSTDVSVDE
170
VKALASLMTY
180
KCAVVDVPFG
190
GAKAGVKINP
200
KNYTENELEK
210
ITRRFTMELA
220
KKGFIGPGVD
230
VPAPDMNTGE
240
REMSWIADTY
250
ASTIGHYDIN
260
AHACVTGKPI
270
SQGGIHGRIS
280
ATGRGVFHGI
290
ENFINEASYM
300
SILGMTPGFR
310
DKTFVVQGFG
320
NVGLHSMRYL
330
HRFGAKCIAV
340
GESDGSIWNP
350
DGIDPKELED
360
FKLQHGSILG
370
FPKAKPYEGS
380
ILEVDCDILI
390
PAATEKQLTK
400
SNAPRVKAKI
410
IAEGANGPTT
420
PEADKIFLER
430
NILVIPDLYL
440
NAGGVTVSYF
450
EWLKNLNHVS
460
YGRLTFKYER
470
DSNYHLLLSV
480
QESLERKFGK
490
HGGTIPIVPT
500
AEFQDSISGA
510
SEKDIVHSAL
520
AYTMERSARQ
530
IMHTAMKYNL
540
GLDLRTAAYV
550
NAIEKVFKVY
SEAGVTFT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0043531 | ADP binding |
| Molecular Function | GO:0004352 | glutamate dehydrogenase (NAD+) activity |
| Molecular Function | GO:0004354 | glutamate dehydrogenase (NADP+) activity |
| Molecular Function | GO:0004353 | glutamate dehydrogenase [NAD(P)+] activity |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0070728 | L-leucine binding |
| Biological Process | GO:0006537 | glutamate biosynthetic process |
| Biological Process | GO:0006536 | glutamate metabolic process |
| Biological Process | GO:0006538 | L-glutamate catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.