Overview
| Uniprot ID | P49454 |
| Protein Name | Centromere protein F |
| Gene Name | CENPF |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 2927 |
RLSSGQNKASGKRQR |
Function
Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia
Protein Sequence
10
MSWALEEWKE
20
GLPTRALQKI
30
QELEGQLDKL
40
KKEKQQRQFQ
50
LDSLEAALQK
60
QKQKVENEKT
70
EGTNLKRENQ
80
RLMEICESLE
90
KTKQKISHEL
100
QVKESQVNFQ
110
EGQLNSGKKQ
120
IEKLEQELKR
130
CKSELERSQQ
140
AAQSADVSLN
150
PCNTPQKIFT
160
TPLTPSQYYS
170
GSKYEDLKEK
180
YNKEVEERKR
190
LEAEVKALQA
200
KKASQTLPQA
210
TMNHRDIARH
220
QASSSVFSWQ
230
QEKTPSHLSS
240
NSQRTPIRRD
250
FSASYFSGEQ
260
EVTPSRSTLQ
270
IGKRDANSSF
280
FDNSSSPHLL
290
DQLKAQNQEL
300
RNKINELELR
310
LQGHEKEMKG
320
QVNKFQELQL
330
QLEKAKVELI
340
EKEKVLNKCR
350
DELVRTTAQY
360
DQASTKYTAL
370
EQKLKKLTED
380
LSCQRQNAES
390
ARCSLEQKIK
400
EKEKEFQEEL
410
SRQQRSFQTL
420
DQECIQMKAR
430
LTQELQQAKN
440
MHNVLQAELD
450
KLTSVKQQLE
460
NNLEEFKQKL
470
CRAEQAFQAS
480
QIKENELRRS
490
MEEMKKENNL
500
LKSHSEQKAR
510
EVCHLEAELK
520
NIKQCLNQSQ
530
NFAEEMKAKN
540
TSQETMLRDL
550
QEKINQQENS
560
LTLEKLKLAV
570
ADLEKQRDCS
580
QDLLKKREHH
590
IEQLNDKLSK
600
TEKESKALLS
610
ALELKKKEYE
620
ELKEEKTLFS
630
CWKSENEKLL
640
TQMESEKENL
650
QSKINHLETC
660
LKTQQIKSHE
670
YNERVRTLEM
680
DRENLSVEIR
690
NLHNVLDSKS
700
VEVETQKLAY
710
MELQQKAEFS
720
DQKHQKEIEN
730
MCLKTSQLTG
740
QVEDLEHKLQ
750
LLSNEIMDKD
760
RCYQDLHAEY
770
ESLRDLLKSK
780
DASLVTNEDH
790
QRSLLAFDQQ
800
PAMHHSFANI
810
IGEQGSMPSE
820
RSECRLEADQ
830
SPKNSAILQN
840
RVDSLEFSLE
850
SQKQMNSDLQ
860
KQCEELVQIK
870
GEIEENLMKA
880
EQMHQSFVAE
890
TSQRISKLQE
900
DTSAHQNVVA
910
ETLSALENKE
920
KELQLLNDKV
930
ETEQAEIQEL
940
KKSNHLLEDS
950
LKELQLLSET
960
LSLEKKEMSS
970
IISLNKREIE
980
ELTQENGTLK
990
EINASLNQEK
1000
MNLIQKSESF
1010
ANYIDEREKS
1020
ISELSDQYKQ
1030
EKLILLQRCE
1040
ETGNAYEDLS
1050
QKYKAAQEKN
1060
SKLECLLNEC
1070
TSLCENRKNE
1080
LEQLKEAFAK
1090
EHQEFLTKLA
1100
FAEERNQNLM
1110
LELETVQQAL
1120
RSEMTDNQNN
1130
SKSEAGGLKQ
1140
EIMTLKEEQN
1150
KMQKEVNDLL
1160
QENEQLMKVM
1170
KTKHECQNLE
1180
SEPIRNSVKE
1190
RESERNQCNF
1200
KPQMDLEVKE
1210
ISLDSYNAQL
1220
VQLEAMLRNK
1230
ELKLQESEKE
1240
KECLQHELQT
1250
IRGDLETSNL
1260
QDMQSQEISG
1270
LKDCEIDAEE
1280
KYISGPHELS
1290
TSQNDNAHLQ
1300
CSLQTTMNKL
1310
NELEKICEIL
1320
QAEKYELVTE
1330
LNDSRSECIT
1340
ATRKMAEEVG
1350
KLLNEVKILN
1360
DDSGLLHGEL
1370
VEDIPGGEFG
1380
EQPNEQHPVS
1390
LAPLDESNSY
1400
EHLTLSDKEV
1410
QMHFAELQEK
1420
FLSLQSEHKI
1430
LHDQHCQMSS
1440
KMSELQTYVD
1450
SLKAENLVLS
1460
TNLRNFQGDL
1470
VKEMQLGLEE
1480
GLVPSLSSSC
1490
VPDSSSLSSL
1500
GDSSFYRALL
1510
EQTGDMSLLS
1520
NLEGAVSANQ
1530
CSVDEVFCSS
1540
LQEENLTRKE
1550
TPSAPAKGVE
1560
ELESLCEVYR
1570
QSLEKLEEKM
1580
ESQGIMKNKE
1590
IQELEQLLSS
1600
ERQELDCLRK
1610
QYLSENEQWQ
1620
QKLTSVTLEM
1630
ESKLAAEKKQ
1640
TEQLSLELEV
1650
ARLQLQGLDL
1660
SSRSLLGIDT
1670
EDAIQGRNES
1680
CDISKEHTSE
1690
TTERTPKHDV
1700
HQICDKDAQQ
1710
DLNLDIEKIT
1720
ETGAVKPTGE
1730
CSGEQSPDTN
1740
YEPPGEDKTQ
1750
GSSECISELS
1760
FSGPNALVPM
1770
DFLGNQEDIH
1780
NLQLRVKETS
1790
NENLRLLHVI
1800
EDRDRKVESL
1810
LNEMKELDSK
1820
LHLQEVQLMT
1830
KIEACIELEK
1840
IVGELKKENS
1850
DLSEKLEYFS
1860
CDHQELLQRV
1870
ETSEGLNSDL
1880
EMHADKSSRE
1890
DIGDNVAKVN
1900
DSWKERFLDV
1910
ENELSRIRSE
1920
KASIEHEALY
1930
LEADLEVVQT
1940
EKLCLEKDNE
1950
NKQKVIVCLE
1960
EELSVVTSER
1970
NQLRGELDTM
1980
SKKTTALDQL
1990
SEKMKEKTQE
2000
LESHQSECLH
2010
CIQVAEAEVK
2020
EKTELLQTLS
2030
SDVSELLKDK
2040
THLQEKLQSL
2050
EKDSQALSLT
2060
KCELENQIAQ
2070
LNKEKELLVK
2080
ESESLQARLS
2090
ESDYEKLNVS
2100
KALEAALVEK
2110
GEFALRLSST
2120
QEEVHQLRRG
2130
IEKLRVRIEA
2140
DEKKQLHIAE
2150
KLKEREREND
2160
SLKDKVENLE
2170
RELQMSEENQ
2180
ELVILDAENS
2190
KAEVETLKTQ
2200
IEEMARSLKV
2210
FELDLVTLRS
2220
EKENLTKQIQ
2230
EKQGQLSELD
2240
KLLSSFKSLL
2250
EEKEQAEIQI
2260
KEESKTAVEM
2270
LQNQLKELNE
2280
AVAALCGDQE
2290
IMKATEQSLD
2300
PPIEEEHQLR
2310
NSIEKLRARL
2320
EADEKKQLCV
2330
LQQLKESEHH
2340
ADLLKGRVEN
2350
LERELEIART
2360
NQEHAALEAE
2370
NSKGEVETLK
2380
AKIEGMTQSL
2390
RGLELDVVTI
2400
RSEKENLTNE
2410
LQKEQERISE
2420
LEIINSSFEN
2430
ILQEKEQEKV
2440
QMKEKSSTAM
2450
EMLQTQLKEL
2460
NERVAALHND
2470
QEACKAKEQN
2480
LSSQVECLEL
2490
EKAQLLQGLD
2500
EAKNNYIVLQ
2510
SSVNGLIQEV
2520
EDGKQKLEKK
2530
DEEISRLKNQ
2540
IQDQEQLVSK
2550
LSQVEGEHQL
2560
WKEQNLELRN
2570
LTVELEQKIQ
2580
VLQSKNASLQ
2590
DTLEVLQSSY
2600
KNLENELELT
2610
KMDKMSFVEK
2620
VNKMTAKETE
2630
LQREMHEMAQ
2640
KTAELQEELS
2650
GEKNRLAGEL
2660
QLLLEEIKSS
2670
KDQLKELTLE
2680
NSELKKSLDC
2690
MHKDQVEKEG
2700
KVREEIAEYQ
2710
LRLHEAEKKH
2720
QALLLDTNKQ
2730
YEVEIQTYRE
2740
KLTSKEECLS
2750
SQKLEIDLLK
2760
SSKEELNNSL
2770
KATTQILEEL
2780
KKTKMDNLKY
2790
VNQLKKENER
2800
AQGKMKLLIK
2810
SCKQLEEEKE
2820
ILQKELSQLQ
2830
AAQEKQKTGT
2840
VMDTKVDELT
2850
TEIKELKETL
2860
EEKTKEADEY
2870
LDKYCSLLIS
2880
HEKLEKAKEM
2890
LETQVAHLCS
2900
QQSKQDSRGS
2910
PLLGPVVPGP
2920
SPIPSVTEKR
2930
LSSGQNKASG
2940
KRQRSSGIWE
2950
NGRGPTPATP
2960
ESFSKKSKKA
2970
VMSGIHPAED
2980
TEGTEFEPEG
2990
LPEVVKKGFA
3000
DIPTGKTSPY
3010
ILRRTTMATR
3020
TSPRLAAQKL
3030
ALSPLSLGKE
3040
NLAESSKPTA
3050
GGSRSQKVKV
3060
AQRSPVDSGT
3070
ILREPTTKSV
3080
PVNNLPERSP
3090
TDSPREGLRV
3100
KRGRLVPSPK
3110
AGLESNGSEN
CKVQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005930 |
axoneme |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0000775 |
chromosome, centromeric region |
| Cellular Component |
GO:0036064 |
ciliary basal body |
| Cellular Component |
GO:0097539 |
ciliary transition fiber |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0030496 |
midbody |
| Cellular Component |
GO:0005635 |
nuclear envelope |
| Cellular Component |
GO:0016363 |
nuclear matrix |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000940 |
outer kinetochore |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0045120 |
pronucleus |
| Cellular Component |
GO:0005819 |
spindle |
| Cellular Component |
GO:0000922 |
spindle pole |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0140297 |
DNA-binding transcription factor binding |
| Molecular Function |
GO:0070840 |
dynein complex binding |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0007059 |
chromosome segregation |
| Biological Process |
GO:0071897 |
DNA biosynthetic process |
| Biological Process |
GO:0001822 |
kidney development |
| Biological Process |
GO:0051382 |
kinetochore assembly |
| Biological Process |
GO:0051310 |
metaphase chromosome alignment |
| Biological Process |
GO:0000278 |
mitotic cell cycle |
| Biological Process |
GO:0007094 |
mitotic spindle assembly checkpoint signaling |
| Biological Process |
GO:0007517 |
muscle organ development |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0010389 |
regulation of G2/M transition of mitotic cell cycle |
| Biological Process |
GO:0009410 |
response to xenobiotic stimulus |
| Biological Process |
GO:0021591 |
ventricular system development |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.