Search Results

Overview

Uniprot IDP49454
Protein NameCentromere protein F
Gene NameCENPF
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2927 RLSSGQNKASGKRQR

Function

Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia

Protein Sequence

10 MSWALEEWKE 20 GLPTRALQKI 30 QELEGQLDKL 40 KKEKQQRQFQ 50 LDSLEAALQK 60 QKQKVENEKT 70 EGTNLKRENQ 80 RLMEICESLE 90 KTKQKISHEL 100 QVKESQVNFQ 110 EGQLNSGKKQ 120 IEKLEQELKR 130 CKSELERSQQ 140 AAQSADVSLN 150 PCNTPQKIFT 160 TPLTPSQYYS 170 GSKYEDLKEK 180 YNKEVEERKR 190 LEAEVKALQA 200 KKASQTLPQA 210 TMNHRDIARH 220 QASSSVFSWQ 230 QEKTPSHLSS 240 NSQRTPIRRD 250 FSASYFSGEQ 260 EVTPSRSTLQ 270 IGKRDANSSF 280 FDNSSSPHLL 290 DQLKAQNQEL 300 RNKINELELR 310 LQGHEKEMKG 320 QVNKFQELQL 330 QLEKAKVELI 340 EKEKVLNKCR 350 DELVRTTAQY 360 DQASTKYTAL 370 EQKLKKLTED 380 LSCQRQNAES 390 ARCSLEQKIK 400 EKEKEFQEEL 410 SRQQRSFQTL 420 DQECIQMKAR 430 LTQELQQAKN 440 MHNVLQAELD 450 KLTSVKQQLE 460 NNLEEFKQKL 470 CRAEQAFQAS 480 QIKENELRRS 490 MEEMKKENNL 500 LKSHSEQKAR 510 EVCHLEAELK 520 NIKQCLNQSQ 530 NFAEEMKAKN 540 TSQETMLRDL 550 QEKINQQENS 560 LTLEKLKLAV 570 ADLEKQRDCS 580 QDLLKKREHH 590 IEQLNDKLSK 600 TEKESKALLS 610 ALELKKKEYE 620 ELKEEKTLFS 630 CWKSENEKLL 640 TQMESEKENL 650 QSKINHLETC 660 LKTQQIKSHE 670 YNERVRTLEM 680 DRENLSVEIR 690 NLHNVLDSKS 700 VEVETQKLAY 710 MELQQKAEFS 720 DQKHQKEIEN 730 MCLKTSQLTG 740 QVEDLEHKLQ 750 LLSNEIMDKD 760 RCYQDLHAEY 770 ESLRDLLKSK 780 DASLVTNEDH 790 QRSLLAFDQQ 800 PAMHHSFANI 810 IGEQGSMPSE 820 RSECRLEADQ 830 SPKNSAILQN 840 RVDSLEFSLE 850 SQKQMNSDLQ 860 KQCEELVQIK 870 GEIEENLMKA 880 EQMHQSFVAE 890 TSQRISKLQE 900 DTSAHQNVVA 910 ETLSALENKE 920 KELQLLNDKV 930 ETEQAEIQEL 940 KKSNHLLEDS 950 LKELQLLSET 960 LSLEKKEMSS 970 IISLNKREIE 980 ELTQENGTLK 990 EINASLNQEK 1000 MNLIQKSESF 1010 ANYIDEREKS 1020 ISELSDQYKQ 1030 EKLILLQRCE 1040 ETGNAYEDLS 1050 QKYKAAQEKN 1060 SKLECLLNEC 1070 TSLCENRKNE 1080 LEQLKEAFAK 1090 EHQEFLTKLA 1100 FAEERNQNLM 1110 LELETVQQAL 1120 RSEMTDNQNN 1130 SKSEAGGLKQ 1140 EIMTLKEEQN 1150 KMQKEVNDLL 1160 QENEQLMKVM 1170 KTKHECQNLE 1180 SEPIRNSVKE 1190 RESERNQCNF 1200 KPQMDLEVKE 1210 ISLDSYNAQL 1220 VQLEAMLRNK 1230 ELKLQESEKE 1240 KECLQHELQT 1250 IRGDLETSNL 1260 QDMQSQEISG 1270 LKDCEIDAEE 1280 KYISGPHELS 1290 TSQNDNAHLQ 1300 CSLQTTMNKL 1310 NELEKICEIL 1320 QAEKYELVTE 1330 LNDSRSECIT 1340 ATRKMAEEVG 1350 KLLNEVKILN 1360 DDSGLLHGEL 1370 VEDIPGGEFG 1380 EQPNEQHPVS 1390 LAPLDESNSY 1400 EHLTLSDKEV 1410 QMHFAELQEK 1420 FLSLQSEHKI 1430 LHDQHCQMSS 1440 KMSELQTYVD 1450 SLKAENLVLS 1460 TNLRNFQGDL 1470 VKEMQLGLEE 1480 GLVPSLSSSC 1490 VPDSSSLSSL 1500 GDSSFYRALL 1510 EQTGDMSLLS 1520 NLEGAVSANQ 1530 CSVDEVFCSS 1540 LQEENLTRKE 1550 TPSAPAKGVE 1560 ELESLCEVYR 1570 QSLEKLEEKM 1580 ESQGIMKNKE 1590 IQELEQLLSS 1600 ERQELDCLRK 1610 QYLSENEQWQ 1620 QKLTSVTLEM 1630 ESKLAAEKKQ 1640 TEQLSLELEV 1650 ARLQLQGLDL 1660 SSRSLLGIDT 1670 EDAIQGRNES 1680 CDISKEHTSE 1690 TTERTPKHDV 1700 HQICDKDAQQ 1710 DLNLDIEKIT 1720 ETGAVKPTGE 1730 CSGEQSPDTN 1740 YEPPGEDKTQ 1750 GSSECISELS 1760 FSGPNALVPM 1770 DFLGNQEDIH 1780 NLQLRVKETS 1790 NENLRLLHVI 1800 EDRDRKVESL 1810 LNEMKELDSK 1820 LHLQEVQLMT 1830 KIEACIELEK 1840 IVGELKKENS 1850 DLSEKLEYFS 1860 CDHQELLQRV 1870 ETSEGLNSDL 1880 EMHADKSSRE 1890 DIGDNVAKVN 1900 DSWKERFLDV 1910 ENELSRIRSE 1920 KASIEHEALY 1930 LEADLEVVQT 1940 EKLCLEKDNE 1950 NKQKVIVCLE 1960 EELSVVTSER 1970 NQLRGELDTM 1980 SKKTTALDQL 1990 SEKMKEKTQE 2000 LESHQSECLH 2010 CIQVAEAEVK 2020 EKTELLQTLS 2030 SDVSELLKDK 2040 THLQEKLQSL 2050 EKDSQALSLT 2060 KCELENQIAQ 2070 LNKEKELLVK 2080 ESESLQARLS 2090 ESDYEKLNVS 2100 KALEAALVEK 2110 GEFALRLSST 2120 QEEVHQLRRG 2130 IEKLRVRIEA 2140 DEKKQLHIAE 2150 KLKEREREND 2160 SLKDKVENLE 2170 RELQMSEENQ 2180 ELVILDAENS 2190 KAEVETLKTQ 2200 IEEMARSLKV 2210 FELDLVTLRS 2220 EKENLTKQIQ 2230 EKQGQLSELD 2240 KLLSSFKSLL 2250 EEKEQAEIQI 2260 KEESKTAVEM 2270 LQNQLKELNE 2280 AVAALCGDQE 2290 IMKATEQSLD 2300 PPIEEEHQLR 2310 NSIEKLRARL 2320 EADEKKQLCV 2330 LQQLKESEHH 2340 ADLLKGRVEN 2350 LERELEIART 2360 NQEHAALEAE 2370 NSKGEVETLK 2380 AKIEGMTQSL 2390 RGLELDVVTI 2400 RSEKENLTNE 2410 LQKEQERISE 2420 LEIINSSFEN 2430 ILQEKEQEKV 2440 QMKEKSSTAM 2450 EMLQTQLKEL 2460 NERVAALHND 2470 QEACKAKEQN 2480 LSSQVECLEL 2490 EKAQLLQGLD 2500 EAKNNYIVLQ 2510 SSVNGLIQEV 2520 EDGKQKLEKK 2530 DEEISRLKNQ 2540 IQDQEQLVSK 2550 LSQVEGEHQL 2560 WKEQNLELRN 2570 LTVELEQKIQ 2580 VLQSKNASLQ 2590 DTLEVLQSSY 2600 KNLENELELT 2610 KMDKMSFVEK 2620 VNKMTAKETE 2630 LQREMHEMAQ 2640 KTAELQEELS 2650 GEKNRLAGEL 2660 QLLLEEIKSS 2670 KDQLKELTLE 2680 NSELKKSLDC 2690 MHKDQVEKEG 2700 KVREEIAEYQ 2710 LRLHEAEKKH 2720 QALLLDTNKQ 2730 YEVEIQTYRE 2740 KLTSKEECLS 2750 SQKLEIDLLK 2760 SSKEELNNSL 2770 KATTQILEEL 2780 KKTKMDNLKY 2790 VNQLKKENER 2800 AQGKMKLLIK 2810 SCKQLEEEKE 2820 ILQKELSQLQ 2830 AAQEKQKTGT 2840 VMDTKVDELT 2850 TEIKELKETL 2860 EEKTKEADEY 2870 LDKYCSLLIS 2880 HEKLEKAKEM 2890 LETQVAHLCS 2900 QQSKQDSRGS 2910 PLLGPVVPGP 2920 SPIPSVTEKR 2930 LSSGQNKASG 2940 KRQRSSGIWE 2950 NGRGPTPATP 2960 ESFSKKSKKA 2970 VMSGIHPAED 2980 TEGTEFEPEG 2990 LPEVVKKGFA 3000 DIPTGKTSPY 3010 ILRRTTMATR 3020 TSPRLAAQKL 3030 ALSPLSLGKE 3040 NLAESSKPTA 3050 GGSRSQKVKV 3060 AQRSPVDSGT 3070 ILREPTTKSV 3080 PVNNLPERSP 3090 TDSPREGLRV 3100 KRGRLVPSPK 3110 AGLESNGSEN CKVQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005930 axoneme
Cellular Component GO:0005813 centrosome
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000775 chromosome, centromeric region
Cellular Component GO:0036064 ciliary basal body
Cellular Component GO:0097539 ciliary transition fiber
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0030496 midbody
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000940 outer kinetochore
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0045120 pronucleus
Cellular Component GO:0005819 spindle
Cellular Component GO:0000922 spindle pole
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0070840 dynein complex binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0030154 cell differentiation
Biological Process GO:0051301 cell division
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0071897 DNA biosynthetic process
Biological Process GO:0001822 kidney development
Biological Process GO:0051382 kinetochore assembly
Biological Process GO:0051310 metaphase chromosome alignment
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0007094 mitotic spindle assembly checkpoint signaling
Biological Process GO:0007517 muscle organ development
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0015031 protein transport
Biological Process GO:0010389 regulation of G2/M transition of mitotic cell cycle
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0021591 ventricular system development

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.