Search Results
Overview
| Uniprot ID | P49458 |
|---|---|
| Protein Name | Signal recognition particle 9 kDa protein |
| Gene Name | SRP9 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 52 | DLVCLVYKTDQAQDV |
| 60 | TDQAQDVKKIEKFHS |
| 76 | LMRLMVAKEARNVTM |
Function
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (PubMed:11089964). The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity)
Protein Sequence
10
MPQYQTWEEF
20
SRAAEKLYLA
30
DPMKARVVLK
40
YRHSDGNLCV
50
KVTDDLVCLV
60
YKTDQAQDVK
70
KIEKFHSQLM
80
RLMVAKEARN
VTMETE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005785 | signal recognition particle receptor complex |
| Cellular Component | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting |
| Molecular Function | GO:0008312 | 7S RNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0005047 | signal recognition particle binding |
| Biological Process | GO:0045900 | negative regulation of translational elongation |
| Biological Process | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane |
| Biological Process | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.