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Overview

Uniprot IDP49589
Protein NameCysteine--tRNA ligase, cytoplasmic
Gene NameCARS1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
10 DSSGQQGKGRRVQPQ

Function

Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys)

Protein Sequence

10 MADSSGQQGK 20 GRRVQPQWSP 30 PAGTQPCRLH 40 LYNSLTRNKE 50 VFIPQDGKKV 60 TWYCCGPTVY 70 DASHMGHARS 80 YISFDILRRV 90 LKDYFKFDVF 100 YCMNITDIDD 110 KIIKRARQNH 120 LFEQYREKRP 130 EAAQLLEDVQ 140 AALKPFSVKL 150 NETTDPDKKQ 160 MLERIQHAVQ 170 LATEPLEKAV 180 QSRLTGEEVN 190 SCVEVLLEEA 200 KDLLSDWLDS 210 TLGCDVTDNS 220 IFSKLPKFWE 230 GDFHRDMEAL 240 NVLPPDVLTR 250 VSEYVPEIVN 260 FVQKIVDNGY 270 GYVSNGSVYF 280 DTAKFASSEK 290 HSYGKLVPEA 300 VGDQKALQEG 310 EGDLSISADR 320 LSEKRSPNDF 330 ALWKASKPGE 340 PSWPCPWGKG 350 RPGWHIECSA 360 MAGTLLGASM 370 DIHGGGFDLR 380 FPHHDNELAQ 390 SEAYFENDCW 400 VRYFLHTGHL 410 TIAGCKMSKS 420 LKNFITIKDA 430 LKKHSARQLR 440 LAFLMHSWKD 450 TLDYSSNTME 460 SALQYEKFLN 470 EFFLNVKDIL 480 RAPVDITGQF 490 EKWGEEEAEL 500 NKNFYDKKTA 510 IHKALCDNVD 520 TRTVMEEMRA 530 LVSQCNLYMA 540 ARKAVRKRPN 550 QALLENIALY 560 LTHMLKIFGA 570 VEEDSSLGFP 580 VGGPGTSLSL 590 EATVMPYLQV 600 LSEFREGVRK 610 IAREQKVPEI 620 LQLSDALRDN 630 ILPELGVRFE 640 DHEGLPTVVK 650 LVDRNTLLKE 660 REEKRRVEEE 670 KRKKKEEAAR 680 RKQEQEAAKL 690 AKMKIPPSEM 700 FLSETDKYSK 710 FDENGLPTHD 720 MEGKELSKGQ 730 AKKLKKLFEA 740 QEKLYKEYLQ MAQNGSFQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004817 cysteine-tRNA ligase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0006423 cysteinyl-tRNA aminoacylation

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.