Search Results
Overview
| Uniprot ID | P49638 |
|---|---|
| Protein Name | Alpha-tocopherol transfer protein |
| Gene Name | TTPA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 178 | ITPSVAKKIAAVLTD |
Function
Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity)
Protein Sequence
10
MAEARSQPSA
20
GPQLNALPDH
30
SPLLQPGLAA
40
LRRRAREAGV
50
PLAPLPLTDS
60
FLLRFLRARD
70
FDLDLAWRLL
80
KNYYKWRAEC
90
PEISADLHPR
100
SIIGLLKAGY
110
HGVLRSRDPT
120
GSKVLIYRIA
130
HWDPKVFTAY
140
DVFRVSLITS
150
ELIVQEVETQ
160
RNGIKAIFDL
170
EGWQFSHAFQ
180
ITPSVAKKIA
190
AVLTDSFPLK
200
VRGIHLINEP
210
VIFHAVFSMI
220
KPFLTEKIKE
230
RIHMHGNNYK
240
QSLLQHFPDI
250
LPLEYGGEEF
260
SMEDICQEWT
270
NFIMKSEDYL
SSISESIQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005770 | late endosome |
| Molecular Function | GO:0120013 | lipid transfer activity |
| Molecular Function | GO:1902936 | phosphatidylinositol bisphosphate binding |
| Molecular Function | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0008431 | vitamin E binding |
| Biological Process | GO:0120009 | intermembrane lipid transfer |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0090212 | negative regulation of establishment of blood-brain barrier |
| Biological Process | GO:0009636 | response to toxic substance |
| Biological Process | GO:0042360 | vitamin E metabolic process |
| Biological Process | GO:0051180 | vitamin transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.