Search Results
Overview
| Uniprot ID | P49710 |
|---|---|
| Protein Name | Hematopoietic lineage cell-specific protein |
| Gene Name | Hcls1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 123 | AARGFGGKYGVERDR |
Function
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression (By similarity)
Protein Sequence
10
MWKSVVGHDV
20
SVSVETQGDD
30
WDTDPDFVND
40
ISEKEQRWGA
50
KTIEGSGRTE
60
HINIHQLRNK
70
VSEEHDILKK
80
KELESGPKAS
90
HGYGGRFGVE
100
RDRMDKSAVG
110
HEYVADVEKH
120
SSQTDAARGF
130
GGKYGVERDR
140
ADKSAVGFDY
150
KGEVEKHASQ
160
KDYSHGFGGR
170
YGVEKDKRDK
180
AALGYDYKGE
190
TEKHESQRDY
200
AKGFGGQYGI
210
QKDRVDKSAV
220
GFNEMEAPTT
230
AYKKTTPIEA
240
ASSGARGLKA
250
KFESLAEEKR
260
KREEEEKAQQ
270
MARQQQERKA
280
VVKMSREVQQ
290
PSMPVEEPAA
300
PAQLPKKISS
310
EVWPPAESHL
320
PPESQPVRSR
330
REYPVPSLPT
340
RQSPLQNHLE
350
DNEEPPALPP
360
RTPEGLQVVE
370
EPVYEAAPEL
380
EPEPEPDYEP
390
EPETEPDYED
400
VGELDRQDED
410
AEGDYEDVLE
420
PEDTPSLSYQ
430
AGPSAGAGGA
440
GISAIALYDY
450
QGEGSDELSF
460
DPDDIITDIE
470
MVDEGWWRGQ
480
CRGHFGLFPA
NYVKLL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0030427 | site of polarized growth |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:0035591 | signaling adaptor activity |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0071345 | cellular response to cytokine stimulus |
| Biological Process | GO:0030218 | erythrocyte differentiation |
| Biological Process | GO:0038158 | granulocyte colony-stimulating factor signaling pathway |
| Biological Process | GO:2000107 | negative regulation of leukocyte apoptotic process |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0051169 | nuclear transport |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0030854 | positive regulation of granulocyte differentiation |
| Biological Process | GO:0045651 | positive regulation of macrophage differentiation |
| Biological Process | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0042307 | positive regulation of protein import into nucleus |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0030833 | regulation of actin filament polymerization |
| Biological Process | GO:0009725 | response to hormone |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.