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Overview

Uniprot IDP49747
Protein NameCartilage oligomeric matrix protein
Gene NameCOMP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
172 GVGLAFAKANKQVCT
63 VREITFLKNTVMECD

Function

Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors (PubMed:16051604, PubMed:16542502). Could play a role in the pathogenesis of osteoarthritis (PubMed:16542502). Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (PubMed:17993464). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity)

Protein Sequence

10 MVPDTACVLL 20 LTLAALGASG 30 QGQSPLGSDL 40 GPQMLRELQE 50 TNAALQDVRE 60 LLRQQVREIT 70 FLKNTVMECD 80 ACGMQQSVRT 90 GLPSVRPLLH 100 CAPGFCFPGV 110 ACIQTESGAR 120 CGPCPAGFTG 130 NGSHCTDVNE 140 CNAHPCFPRV 150 RCINTSPGFR 160 CEACPPGYSG 170 PTHQGVGLAF 180 AKANKQVCTD 190 INECETGQHN 200 CVPNSVCINT 210 RGSFQCGPCQ 220 PGFVGDQASG 230 CQRRAQRFCP 240 DGSPSECHEH 250 ADCVLERDGS 260 RSCVCAVGWA 270 GNGILCGRDT 280 DLDGFPDEKL 290 RCPERQCRKD 300 NCVTVPNSGQ 310 EDVDRDGIGD 320 ACDPDADGDG 330 VPNEKDNCPL 340 VRNPDQRNTD 350 EDKWGDACDN 360 CRSQKNDDQK 370 DTDQDGRGDA 380 CDDDIDGDRI 390 RNQADNCPRV 400 PNSDQKDSDG 410 DGIGDACDNC 420 PQKSNPDQAD 430 VDHDFVGDAC 440 DSDQDQDGDG 450 HQDSRDNCPT 460 VPNSAQEDSD 470 HDGQGDACDD 480 DDDNDGVPDS 490 RDNCRLVPNP 500 GQEDADRDGV 510 GDVCQDDFDA 520 DKVVDKIDVC 530 PENAEVTLTD 540 FRAFQTVVLD 550 PEGDAQIDPN 560 WVVLNQGREI 570 VQTMNSDPGL 580 AVGYTAFNGV 590 DFEGTFHVNT 600 VTDDDYAGFI 610 FGYQDSSSFY 620 VVMWKQMEQT 630 YWQANPFRAV 640 AEPGIQLKAV 650 KSSTGPGEQL 660 RNALWHTGDT 670 ESQVRLLWKD 680 PRNVGWKDKK 690 SYRWFLQHRP 700 QVGYIRVRFY 710 EGPELVADSN 720 VVLDTTMRGG 730 RLGVFCFSQE 740 NIIWANLRYR 750 CNDTIPEDYE THQLRQA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:1990341 thrombospondin complex
Molecular Function GO:0036122 BMP binding
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005518 collagen binding
Molecular Function GO:0005201 extracellular matrix structural constituent
Molecular Function GO:0043395 heparan sulfate proteoglycan binding
Molecular Function GO:0008201 heparin binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0002020 protease binding
Molecular Function GO:0043394 proteoglycan binding
Biological Process GO:0009887 animal organ morphogenesis
Biological Process GO:0006915 apoptotic process
Biological Process GO:1990079 cartilage homeostasis
Biological Process GO:0007155 cell adhesion
Biological Process GO:0060173 limb development
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0001501 skeletal system development

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.