Search Results

Overview

Uniprot IDP49750
Protein NameYLP motif-containing protein 1
Gene NameYLPM1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1092 RPGSSREKVPGGLQG
1475 EQKEQLQKMKDFGSE
1652 GRDISTNKVEQIPYG
1769 DRPSYDRKSDRPVYE
2044 LGYIPKSKWEMDTSE
2056 TSEAKLDKLDGLRTG
2138 ESGHLAEKALNRTKY
310 LSLQQRTKVHLPGHK
317 KVHLPGHKKGPVVAK
706 NSKAPLSKSALPYSS
808 PAEGTKSKWGMIPRG
838 RQSGPQWKGPKPAFG
875 DTSSNQQKNFKMQSA

Function

Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation

Protein Sequence

10 MYPNWGRYGG 20 SSHYPPPPVP 30 PPPPVALPEA 40 SPGPGYSSST 50 TPAAPSSSGF 60 MSFREQHLAQ 70 LQQLQQMHQK 80 QMQCVLQPHH 90 LPPPPLPPPP 100 VMPGGGYGDW 110 QPPPPPMPPP 120 PGPALSYQKQ 130 QQYKHQMLHH 140 QRDGPPGLVP 150 MELESPPESP 160 PVPPGSYMPP 170 SQSYMPPPQP 180 PPSYYPPTSS 190 QPYLPPAQPS 200 PSQSPPSQSY 210 LAPTPSYSSS 220 SSSSQSYLSH 230 SQSYLPSSQA 240 SPSRPSQGHS 250 KSQLLAPPPP 260 SAPPGNKTTV 270 QQEPLESGAK 280 NKSTEQQQAA 290 PEPDPSTMTP 300 QEQQQYWYRQ 310 HLLSLQQRTK 320 VHLPGHKKGP 330 VVAKDTPEPV 340 KEEVTVPATS 350 QVPESPSSEE 360 PPLPPPNEEV 370 PPPLPPEEPQ 380 SEDPEEDARL 390 KQLQAAAAHW 400 QQHQQHRVGF 410 QYQGIMQKHT 420 QLQQILQQYQ 430 QIIQPPPHIQ 440 TMSVDMQLRH 450 YEMQQQQFQH 460 LYQEWEREFQ 470 LWEEQLHSYP 480 HKDQLQEYEK 490 QWKTWQGHMK 500 ATQSYLQEKV 510 NSFQNMKNQY 520 MGNMSMPPPF 530 VPYSQMPPPL 540 PTMPPPVLPP 550 SLPPPVMPPA 560 LPATVPPPGM 570 PPPVMPPSLP 580 TSVPPPGMPP 590 SLSSAGPPPV 600 LPPPSLSSAG 610 PPPVLPPPSL 620 SSTAPPPVMP 630 LPPLSSATPP 640 PGIPPPGVPQ 650 GIPPQLTAAP 660 VPPASSSQSS 670 QVPEKPRPAL 680 LPTPVSFGSA 690 PPTTYHPPLQ 700 SAGPSEQVNS 710 KAPLSKSALP 720 YSSFSSDQGL 730 GESSAAPSQP 740 ITAVKDMPVR 750 SGGLLPDPPR 760 SSYLESPRGP 770 RFDGPRRFED 780 LGSRCEGPRP 790 KGPRFEGNRP 800 DGPRPRYEGH 810 PAEGTKSKWG 820 MIPRGPASQF 830 YITPSTSLSP 840 RQSGPQWKGP 850 KPAFGQQHQQ 860 QPKSQAEPLS 870 GNKEPLADTS 880 SNQQKNFKMQ 890 SAAFSIAADV 900 KDVKAAQSNE 910 NLSDSQQEPP 920 KSEVSEGPVE 930 PSNWDQNVQS 940 METQIDKAQA 950 VTQPVPLANK 960 PVPAQSTFPS 970 KTGGMEGGTA 980 VATSSLTADN 990 DFKPVGIGLP 1000 HSENNQDKGL 1010 PRPDNRDNRL 1020 EGNRGNSSSY 1030 RGPGQSRMED 1040 TRDKGLVNRG 1050 RGQAISRGPG 1060 LVKQEDFRDK 1070 MMGRREDSRE 1080 KMNRGEGSRD 1090 RGLVRPGSSR 1100 EKVPGGLQGS 1110 QDRGAAGSRE 1120 RGPPRRAGSQ 1130 ERGPLRRAGS 1140 RERIPPRRAG 1150 SRERGPPRGP 1160 GSRERGLGRS 1170 DFGRDRGPFR 1180 PEPGDGGEKM 1190 YPYHRDEPPR 1200 APWNHGEERG 1210 HEEFPLDGRN 1220 APMERERLDD 1230 WDRERYWREC 1240 ERDYQDDTLE 1250 LYNREDRFSA 1260 PPSRSHDGDR 1270 RGPWWDDWER 1280 DQDMDEDYNR 1290 EMERDMDRDV 1300 DRISRPMDMY 1310 DRSLDNEWDR 1320 DYGRPLDEQE 1330 SQFRERDIPS 1340 LPPLPPLPPL 1350 PPLDRYRDDR 1360 WREERNREHG 1370 YDRDFRDRGE 1380 LRIREYPERG 1390 DTWREKRDYV 1400 PDRMDWERER 1410 LSDRWYPSDV 1420 DRHSPMAEHM 1430 PSSHHSSEMM 1440 GSDASLDSDQ 1450 GLGGVMVLSQ 1460 RQHEIILKAA 1470 QELKMLREQK 1480 EQLQKMKDFG 1490 SEPQMADHLP 1500 PQESRLQNTS 1510 SRPGMYPPPG 1520 SYRPPPPMGK 1530 PPGSIVRPSA 1540 PPARSSVPVT 1550 RPPVPIPPPP 1560 PPPPLPPPPP 1570 VIKPQTSAVE 1580 QERWDEDSFY 1590 GLWDTNDEQG 1600 LNSEFKSETA 1610 AIPSAPVLPP 1620 PPVHSSIPPP 1630 GPVPMGMPPM 1640 SKPPPVQQTV 1650 DYGHGRDIST 1660 NKVEQIPYGE 1670 RITLRPDPLP 1680 ERSTFETEHA 1690 GQRDRYDRER 1700 DREPYFDRQS 1710 NVIADHRDFK 1720 RDRETHRDRD 1730 RDRGVIDYDR 1740 DRFDRERRPR 1750 DDRAQSYRDK 1760 KDHSSSRRGG 1770 FDRPSYDRKS 1780 DRPVYEGPSM 1790 FGGERRTYPE 1800 ERMPLPAPSL 1810 SHQPPPAPRV 1820 EKKPESKNVD 1830 DILKPPGRES 1840 RPERIVVIMR 1850 GLPGSGKTHV 1860 AKLIRDKEVE 1870 FGGPAPRVLS 1880 LDDYFITEVE 1890 KEEKDPDSGK 1900 KVKKKVMEYE 1910 YEAEMEETYR 1920 TSMFKTFKKT 1930 LDDGFFPFII 1940 LDAINDRVRH 1950 FDQFWSAAKT 1960 KGFEVYLAEM 1970 SADNQTCGKR 1980 NIHGRKLKEI 1990 NKMADHWETA 2000 PRHMMRLDIR 2010 SLLQDAAIEE 2020 VEMEDFDANI 2030 EEQKEEKKDA 2040 EEEESELGYI 2050 PKSKWEMDTS 2060 EAKLDKLDGL 2070 RTGTKRKRDW 2080 EAIASRMEDY 2090 LQLPDDYDTR 2100 ASEPGKKRVR 2110 WADLEEKKDA 2120 DRKRAIGFVV 2130 GQTDWEKITD 2140 ESGHLAEKAL NRTKYI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0032204 regulation of telomere maintenance

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.