Search Results
Overview
| Uniprot ID | P49770 |
|---|---|
| Protein Name | Translation initiation factor eIF2B subunit beta |
| Gene Name | EIF2B2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 7 | *MPGSAAKGSELSER |
Function
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492)
Protein Sequence
10
MPGSAAKGSE
20
LSERIESFVE
30
TLKRGGGPRS
40
SEEMARETLG
50
LLRQIITDHR
60
WSNAGELMEL
70
IRREGRRMTA
80
AQPSETTVGN
90
MVRRVLKIIR
100
EEYGRLHGRS
110
DESDQQESLH
120
KLLTSGGLNE
130
DFSFHYAQLQ
140
SNIIEAINEL
150
LVELEGTMEN
160
IAAQALEHIH
170
SNEVIMTIGF
180
SRTVEAFLKE
190
AARKRKFHVI
200
VAECAPFCQG
210
HEMAVNLSKA
220
GIETTVMTDA
230
AIFAVMSRVN
240
KVIIGTKTIL
250
ANGALRAVTG
260
THTLALAAKH
270
HSTPLIVCAP
280
MFKLSPQFPN
290
EEDSFHKFVA
300
PEEVLPFTEG
310
DILEKVSVHC
320
PVFDYVPPEL
330
ITLFISNIGG
340
NAPSYIYRLM
350
SELYHPDDHV
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005851 | eukaryotic translation initiation factor 2B complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Molecular Function | GO:0003743 | translation initiation factor activity |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0002183 | cytoplasmic translational initiation |
| Biological Process | GO:0042552 | myelination |
| Biological Process | GO:0014003 | oligodendrocyte development |
| Biological Process | GO:0001541 | ovarian follicle development |
| Biological Process | GO:0045948 | positive regulation of translational initiation |
| Biological Process | GO:0006446 | regulation of translational initiation |
| Biological Process | GO:0009749 | response to glucose |
| Biological Process | GO:0009408 | response to heat |
| Biological Process | GO:0043434 | response to peptide hormone |
| Biological Process | GO:0050852 | T cell receptor signaling pathway |
| Biological Process | GO:0006413 | translational initiation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.