Search Results

Overview

Uniprot IDP49790
Protein NameNuclear pore complex protein Nup153
Gene NameNUP153
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1071 TCKTSEAKKEEMPAT
15 VGGGGGGKIRTRRCH
317 RILQSLEKMSSPLAD
326 SSPLADAKRIPSIVS
353 DITDFQAKREKVDSQ
403 TNQRIDNKCSTGYEK
613 GSVLDILKSPGFASP
702 TGIETPNKSGKTTLS
705 ETPNKSGKTTLSASG
718 SGTGFGDKFKPVIGT
720 TGFGDKFKPVIGTWD
849 SLGLEKFKKPEGSWD
886 PGTKSGFKGFDTSSS

Function

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC)

Protein Sequence

10 MASGAGGVGG 20 GGGGKIRTRR 30 CHQGPIKPYQ 40 QGRQQHQGIL 50 SRVTESVKNI 60 VPGWLQRYFN 70 KNEDVCSCST 80 DTSEVPRWPE 90 NKEDHLVYAD 100 EESSNITDGR 110 ITPEPAVSNT 120 EEPSTTSTAS 130 NYPDVLTRPS 140 LHRSHLNFSM 150 LESPALHCQP 160 STSSAFPIGS 170 SGFSLVKEIK 180 DSTSQHDDDN 190 ISTTSGFSSR 200 ASDKDITVSK 210 NTSLPPLWSP 220 EAERSHSLSQ 230 HTATSSKKPA 240 FNLSAFGTLS 250 PSLGNSSILK 260 TSQLGDSPFY 270 PGKTTYGGAA 280 AAVRQSKLRN 290 TPYQAPVRRQ 300 MKAKQLSAQS 310 YGVTSSTARR 320 ILQSLEKMSS 330 PLADAKRIPS 340 IVSSPLNSPL 350 DRSGIDITDF 360 QAKREKVDSQ 370 YPPVQRLMTP 380 KPVSIATNRS 390 VYFKPSLTPS 400 GEFRKTNQRI 410 DNKCSTGYEK 420 NMTPGQNREQ 430 RESGFSYPNF 440 SLPAANGLSS 450 GVGGGGGKMR 460 RERTRFVASK 470 PLEEEEMEVP 480 VLPKISLPIT 490 SSSLPTFNFS 500 SPEITTSSPS 510 PINSSQALTN 520 KVQMTSPSST 530 GSPMFKFSSP 540 IVKSTEANVL 550 PPSSIGFTFS 560 VPVAKTAELS 570 GSSSTLEPII 580 SSSAHHVTTV 590 NSTNCKKTPP 600 EDCEGPFRPA 610 EILKEGSVLD 620 ILKSPGFASP 630 KIDSVAAQPT 640 ATSPVVYTRP 650 AISSFSSSGI 660 GFGESLKAGS 670 SWQCDTCLLQ 680 NKVTDNKCIA 690 CQAAKLSPRD 700 TAKQTGIETP 710 NKSGKTTLSA 720 SGTGFGDKFK 730 PVIGTWDCDT 740 CLVQNKPEAI 750 KCVACETPKP 760 GTCVKRALTL 770 TVVSESAETM 780 TASSSSCTVT 790 TGTLGFGDKF 800 KRPIGSWECS 810 VCCVSNNAED 820 NKCVSCMSEK 830 PGSSVPASSS 840 STVPVSLPSG 850 GSLGLEKFKK 860 PEGSWDCELC 870 LVQNKADSTK 880 CLACESAKPG 890 TKSGFKGFDT 900 SSSSSNSAAS 910 SSFKFGVSSS 920 SSGPSQTLTS 930 TGNFKFGDQG 940 GFKIGVSSDS 950 GSINPMSEGF 960 KFSKPIGDFK 970 FGVSSESKPE 980 EVKKDSKNDN 990 FKFGLSSGLS 1000 NPVSLTPFQF 1010 GVSNLGQEEK 1020 KEELPKSSSA 1030 GFSFGTGVIN 1040 STPAPANTIV 1050 TSENKSSFNL 1060 GTIETKSASV 1070 APFTCKTSEA 1080 KKEEMPATKG 1090 GFSFGNVEPA 1100 SLPSASVFVL 1110 GRTEEKQQEP 1120 VTSTSLVFGK 1130 KADNEEPKCQ 1140 PVFSFGNSEQ 1150 TKDENSSKST 1160 FSFSMTKPSE 1170 KESEQPAKAT 1180 FAFGAQTSTT 1190 ADQGAAKPVF 1200 SFLNNSSSSS 1210 STPATSAGGG 1220 IFGSSTSSSN 1230 PPVATFVFGQ 1240 SSNPVSSSAF 1250 GNTAESSTSQ 1260 SLLFSQDSKL 1270 ATTSSTGTAV 1280 TPFVFGPGAS 1290 SNNTTTSGFG 1300 FGATTTSSSA 1310 GSSFVFGTGP 1320 SAPSASPAFG 1330 ANQTPTFGQS 1340 QGASQPNPPG 1350 FGSISSSTAL 1360 FPTGSQPAPP 1370 TFGTVSSSSQ 1380 PPVFGQQPSQ 1390 SAFGSGTTPN 1400 SSSAFQFGSS 1410 TTNFNFTNNS 1420 PSGVFTFGAN 1430 SSTPAASAQP 1440 SGSGGFPFNQ 1450 SPAAFTVGSN 1460 GKNVFSSSGT 1470 SFSGRKIKTA VRRRK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0043657 host cell
Cellular Component GO:0016020 membrane
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0042405 nuclear inclusion body
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0034399 nuclear periphery
Cellular Component GO:0005643 nuclear pore
Cellular Component GO:0044615 nuclear pore nuclear basket
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0140693 molecular condensate scaffold activity
Molecular Function GO:0008139 nuclear localization sequence binding
Molecular Function GO:0043495 protein-membrane adaptor activity
Molecular Function GO:0017056 structural constituent of nuclear pore
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:1990000 amyloid fibril formation
Biological Process GO:0051028 mRNA transport
Biological Process GO:0046832 negative regulation of RNA export from nucleus
Biological Process GO:0051292 nuclear pore complex assembly
Biological Process GO:0006913 nucleocytoplasmic transport
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0006405 RNA export from nucleus
Biological Process GO:0046718 symbiont entry into host cell
Biological Process GO:0075732 viral penetration into host nucleus

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.