Search Results

Overview

Uniprot ID	P49793
Protein Name	Nuclear pore complex protein Nup98-Nup96
Gene Name	Nup98
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
1039	ISASHSSKSRSIVGG
542	PTNPAAQKALTTPTH
551	LTTPTHYKLTPRPAT
563	PATRVRPKALQTTGT

Function

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC

Protein Sequence

10 MFNKSFGTPF 20 GGGTGGFGTT 30 STFGQNTGFG 40 TTSGGAFGTS 50 AFGSSNNTGG 60 LFGNSQTKPG 70 GLFGTSSFSQ 80 PATSTSTGFG 90 FGTSTGTSNS 100 LFGTANTGTS 110 LFSSQNNAFA 120 QNKPTGFGNF 130 GTSTSSGGLF 140 GTTNTTSNPF 150 GNTSGSLFGP 160 SSFTAAPTGT 170 TIKFNPPTGT 180 DTMVKAGVST 190 NISTKHQCIT 200 AMKEYESKSL 210 EELRLEDYQA 220 NRKGPQNQVG 230 AGTTTGLFGS 240 SPATSSATGL 250 FSSSTTNSAF 260 SYGQNKTAFG 270 TSTTGFGTNP 280 GGLFGQQNQQ 290 TTSLFSKPFG 300 QATTTPNTGF 310 SFGNTSTLGQ 320 PSTNTMGLFG 330 VTQASQPGGL 340 FGTATNTSTG 350 TAFGTGTGLF 360 GQPNTGFGAV 370 GSTLFGNNKL 380 TTFGTSTTSA 390 PSFGTTSGGL 400 FGNKPTLTLG 410 TNTNTSNFGF 420 GTNNSGSSIF 430 GSKPAAGTLG 440 TGLGTGFGTA 450 LGAGQASLFG 460 NNQPKIGGPL 470 GTGAFGAPGF 480 NTSTAILGFG 490 APQAPVALTD 500 PNASAAQQAV 510 LQQHLNSLTY 520 SPFGDSPLFR 530 NPMSDPKKKE 540 ERLKPTNPAA 550 QKALTTPTHY 560 KLTPRPATRV 570 RPKALQTTGT 580 AKSHLFDGLD 590 DDEPSLANGA 600 FMPKKSIKKL 610 VLKNLNNSNL 620 FSPVNHDSED 630 LASPSEYPEN 640 GERFSFLSKP 650 VDENHQQDGD 660 DDSLVSRFYT 670 NPIAKPIPQT 680 PESAGNKNNS 690 SSNVEDTFIA 700 LNMRAALRNG 710 LEGSSEETSF 720 HDESLQDDRD 730 EIENSAFQIH 740 PAGIVLTKVG 750 YYTIPSMDDL 760 AKITNEKGEC 770 IVSDFTIGRK 780 GYGSIYFEGD 790 VNLTNLNLDD 800 IVHIRRKEVI 810 VYVDDNQKPP 820 VGEGLNRKAE 830 VTLDGVWPTD 840 KTSRCLIKSP 850 DRLADINYEG 860 RLEAVSRKQG 870 AQFKEYRPET 880 GSWVFKVSHF 890 SKYGLQDSDE 900 EEEEHPPKTT 910 SKKLKTAPLP 920 PAGQATTFQM 930 TLNGKPAPPP 940 QSQSPEVEQL 950 GRVVELDSDM 960 VDITQEPVPD 970 SVLEESVPED 980 QEPVSASTQI 990 ASSLGINPHV 1000 LQIMKASLLV 1010 DEEDVDAMEQ 1020 RFGHFPSRGD 1030 TAQEICSPRL 1040 PISASHSSKS 1050 RSIVGGLLQS 1060 KFASGTFLSP 1070 SASVQECRTP 1080 RTSSLMNVPS 1090 TSPWSVPLPL 1100 ATVFTVPSPA 1110 PEVPLKTVGI 1120 RRQPGLVPLE 1130 KSITYGKGKL 1140 LMDMALFMGR 1150 SFRVGWGPNW 1160 TLANSGEQLH 1170 GSHELENHQV 1180 AESMEYGFLP 1190 NPVAVKSLSE 1200 SPFKVHLEKL 1210 GLRQRKLDED 1220 LQLYQTPLEL 1230 KLKHSTVHVD 1240 ELCPLIVPNP 1250 GVSVIHGYAD 1260 WVKKSPRDLL 1270 ELPIVKHWSL 1280 TWTLCEALWG 1290 HLKELDSQLD 1300 EPSEYIQTLE 1310 RRRAFSRWLS 1320 HTAAPQIEEE 1330 VSLTRRDSPI 1340 EAVFSYLTGS 1350 RISEACCLAQ 1360 QSGDHRLALL 1370 LSQLVGSQSV 1380 RELLTMQLAD 1390 WHQLQADSFI 1400 HDERLRIFAL 1410 LAGKPVWQLS 1420 EQKQINVCSQ 1430 LDWKRTLAIH 1440 LWYLLPPTAS 1450 ISRALSMYEE 1460 AFQNTCEGDK 1470 YACPPLPSYL 1480 EGSGCVVEEE 1490 KDPQRPLQDV 1500 CFHLLKLYSD 1510 RHYGLNQLLE 1520 PRSITADPLD 1530 YRLSWHLWEV 1540 LRALNYTHLS 1550 EQCEGVLQAS 1560 YAGQLESEGL 1570 WEWAIFVFLH 1580 IDNSGMREKA 1590 VRELLTRHCQ 1600 LSETPESWAK 1610 ETFLTQKLCV 1620 PAEWIHEAKA 1630 VRAHMESNKH 1640 LEALYLFKAG 1650 HWNRCHKLVV 1660 RHLASDAIIN 1670 ENYDYLKGFL 1680 EDLAPPERSS 1690 LIQDWETSGL 1700 VYLDYIRVIE 1710 MLHRIQQVDC 1720 SGYELEHLHT 1730 KVTSLCNRIE 1740 QIPCYNAKDR 1750 LAQSDMAKRV 1760 ANLLRVVLSL 1770 QHTPDATSNS 1780 TPDPQRVPLR 1790 LLAPHIGRLP 1800 MPEDYALEEL 1810 RGLTQSYLRE LTVGSQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0042405	nuclear inclusion body
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0034399	nuclear periphery
Cellular Component	GO:0005643	nuclear pore
Cellular Component	GO:0044614	nuclear pore cytoplasmic filaments
Cellular Component	GO:0044615	nuclear pore nuclear basket
Cellular Component	GO:0031080	nuclear pore outer ring
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:1990904	ribonucleoprotein complex
Molecular Function	GO:0140693	molecular condensate scaffold activity
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0008139	nuclear localization sequence binding
Molecular Function	GO:0042277	peptide binding
Molecular Function	GO:1990841	promoter-specific chromatin binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0008236	serine-type peptidase activity
Molecular Function	GO:0017056	structural constituent of nuclear pore
Molecular Function	GO:0003713	transcription coactivator activity
Biological Process	GO:0051028	mRNA transport
Biological Process	GO:0051292	nuclear pore complex assembly
Biological Process	GO:0048026	positive regulation of mRNA splicing, via spliceosome
Biological Process	GO:0000973	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
Biological Process	GO:0006606	protein import into nucleus
Biological Process	GO:0006508	proteolysis
Biological Process	GO:0006405	RNA export from nucleus
Biological Process	GO:0034398	telomere tethering at nuclear periphery

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.