Search Results
Overview
| Uniprot ID | P49806 |
|---|---|
| Protein Name | Regulator of G protein signaling 10 |
| Gene Name | Rgs10 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 12 | AVSRLSRKRPPSDIH |
Function
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G protein
Protein Sequence
10
MFTRAVSRLS
20
RKRPPSDIHD
30
GDGSSSSGHQ
40
SLKSTAKWAS
50
SLENLLEDPE
60
GVKRFREFLK
70
KEFSEENVLF
80
WLACEDFKKT
90
EDKKQMQEKA
100
KKIYMTFLSN
110
KASSQVNVEG
120
QSRLTEKILE
130
EPHPLMFQKL
140
QDQIFNLMKY
150
DSYSRFLKSD
160
LFLKHRRTEE
170
EEEDPPDAQT
180
AAKRASRIYN
T
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043679 | axon terminus |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0001965 | G-protein alpha-subunit binding |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Biological Process | GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway |
| Biological Process | GO:0009968 | negative regulation of signal transduction |
| Biological Process | GO:0043547 | positive regulation of GTPase activity |
| Biological Process | GO:0008277 | regulation of G protein-coupled receptor signaling pathway |
| Biological Process | GO:0001975 | response to amphetamine |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.