Overview
| Uniprot ID | P49821 |
|---|
| Protein Name | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |
|---|
| Gene Name | NDUFV1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 54 |
GRHDWRLKGSLSRGD |
| 66 |
RGDWYKTKEILLKGP |
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:28844695). Part of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone (PubMed:28844695). Contains FMN, which is the initial electron acceptor as well as one iron-sulfur cluster (PubMed:28844695)
Protein Sequence
10
MLATRRLLGW
20
SLPARVSVRF
30
SGDTTAPKKT
40
SFGSLKDEDR
50
IFTNLYGRHD
60
WRLKGSLSRG
70
DWYKTKEILL
80
KGPDWILGEI
90
KTSGLRGRGG
100
AGFPTGLKWS
110
FMNKPSDGRP
120
KYLVVNADEG
130
EPGTCKDREI
140
LRHDPHKLLE
150
GCLVGGRAMG
160
ARAAYIYIRG
170
EFYNEASNLQ
180
VAIREAYEAG
190
LIGKNACGSG
200
YDFDVFVVRG
210
AGAYICGEET
220
ALIESIEGKQ
230
GKPRLKPPFP
240
ADVGVFGCPT
250
TVANVETVAV
260
SPTICRRGGT
270
WFAGFGRERN
280
SGTKLFNISG
290
HVNHPCTVEE
300
EMSVPLKELI
310
EKHAGGVTGG
320
WDNLLAVIPG
330
GSSTPLIPKS
340
VCETVLMDFD
350
ALVQAQTGLG
360
TAAVIVMDRS
370
TDIVKAIARL
380
IEFYKHESCG
390
QCTPCREGVD
400
WMNKVMARFV
410
RGDARPAEID
420
SLWEISKQIE
430
GHTICALGDG
440
AAWPVQGLIR
450
HFRPELEERM
460
QRFAQQHQAR
QAAS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0045271 |
respiratory chain complex I |
| Molecular Function |
GO:0051539 |
4 iron, 4 sulfur cluster binding |
| Molecular Function |
GO:0010181 |
FMN binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0051287 |
NAD binding |
| Molecular Function |
GO:0008137 |
NADH dehydrogenase (ubiquinone) activity |
| Molecular Function |
GO:0016491 |
oxidoreductase activity |
| Biological Process |
GO:0009060 |
aerobic respiration |
| Biological Process |
GO:0042775 |
mitochondrial ATP synthesis coupled electron transport |
| Biological Process |
GO:0006120 |
mitochondrial electron transport, NADH to ubiquinone |
| Biological Process |
GO:0042776 |
proton motive force-driven mitochondrial ATP synthesis |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.