Overview
| Uniprot ID | P49888 |
|---|
| Protein Name | Sulfotransferase 1E1 |
|---|
| Gene Name | SULT1E1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 213 |
LIHFLERKPSEELVD |
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:11006110, PubMed:11884392, PubMed:7779757). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency (PubMed:11006110, PubMed:19589875). Does not sulfonate cortisol, testosterone and dopamine (PubMed:11006110, PubMed:7779757). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system
Protein Sequence
10
MNSELDYYEK
20
FEEVHGILMY
30
KDFVKYWDNV
40
EAFQARPDDL
50
VIATYPKSGT
60
TWVSEIVYMI
70
YKEGDVEKCK
80
EDVIFNRIPF
90
LECRKENLMN
100
GVKQLDEMNS
110
PRIVKTHLPP
120
ELLPASFWEK
130
DCKIIYLCRN
140
AKDVAVSFYY
150
FFLMVAGHPN
160
PGSFPEFVEK
170
FMQGQVPYGS
180
WYKHVKSWWE
190
KGKSPRVLFL
200
FYEDLKEDIR
210
KEVIKLIHFL
220
ERKPSEELVD
230
RIIHHTSFQE
240
MKNNPSTNYT
250
TLPDEIMNQK
260
LSPFMRKGIT
270
GDWKNHFTVA
280
LNEKFDKHYE
290
QQMKESTLKF
RTEI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0004062 |
aryl sulfotransferase activity |
| Molecular Function |
GO:0004304 |
estrone sulfotransferase activity |
| Molecular Function |
GO:0047894 |
flavonol 3-sulfotransferase activity |
| Molecular Function |
GO:0005496 |
steroid binding |
| Molecular Function |
GO:0050294 |
steroid sulfotransferase activity |
| Molecular Function |
GO:0008146 |
sulfotransferase activity |
| Biological Process |
GO:0050427 |
3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| Biological Process |
GO:0006711 |
estrogen catabolic process |
| Biological Process |
GO:0008210 |
estrogen metabolic process |
| Biological Process |
GO:0006068 |
ethanol catabolic process |
| Biological Process |
GO:0045600 |
positive regulation of fat cell differentiation |
| Biological Process |
GO:0008202 |
steroid metabolic process |
| Biological Process |
GO:0051923 |
sulfation |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.