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Overview

Uniprot IDP49913
Protein NameCathelicidin antimicrobial peptide
Gene NameCAMP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
127 SFDISCDKDNKRFAL

Function

Antimicrobial protein that is an integral component of the innate immune system (PubMed:14978112, PubMed:16637646, PubMed:18818205, PubMed:22879591, PubMed:9736536). Binds to bacterial lipopolysaccharides (LPS) (PubMed:16637646, PubMed:18818205). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). Postsecretory processing generates multiple cathelicidin antimicrobial peptides with various lengths which act as a topical antimicrobial defense in sweat on skin (PubMed:14978112). The unprocessed precursor form, cathelicidin antimicrobial peptide, inhibits the growth of Gram-negative E.coli and E.aerogenes with efficiencies comparable to that of the mature peptide LL-37 (in vitro) (PubMed:9736536)

Protein Sequence

10 MKTQRDGHSL 20 GRWSLVLLLL 30 GLVMPLAIIA 40 QVLSYKEAVL 50 RAIDGINQRS 60 SDANLYRLLD 70 LDPRPTMDGD 80 PDTPKPVSFT 90 VKETVCPRTT 100 QQSPEDCDFK 110 KDGLVKRCMG 120 TVTLNQARGS 130 FDISCDKDNK 140 RFALLGDFFR 150 KSKEKIGKEF 160 KRIVQRIKDF 170 LRNLVPRTES

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042995 cell projection
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0042581 specific granule
Cellular Component GO:0035580 specific granule lumen
Cellular Component GO:1904724 tertiary granule lumen
Molecular Function GO:0001530 lipopolysaccharide binding
Biological Process GO:1990000 amyloid fibril formation
Biological Process GO:0019731 antibacterial humoral response
Biological Process GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Biological Process GO:1903545 cellular response to butyrate
Biological Process GO:0071360 cellular response to exogenous dsRNA
Biological Process GO:0071347 cellular response to interleukin-1
Biological Process GO:0071354 cellular response to interleukin-6
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0071224 cellular response to peptidoglycan
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0019835 cytolysis
Biological Process GO:0042742 defense response to bacterium
Biological Process GO:0050829 defense response to Gram-negative bacterium
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0097187 dentinogenesis
Biological Process GO:0045087 innate immune response
Biological Process GO:0002227 innate immune response in mucosa
Biological Process GO:0051873 killing by host of symbiont cells
Biological Process GO:0019370 leukotriene biosynthetic process
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0042119 neutrophil activation
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0002760 positive regulation of antimicrobial humoral response
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
Biological Process GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:0032731 positive regulation of interleukin-1 beta production
Biological Process GO:0071642 positive regulation of macrophage inflammatory protein 1 alpha production
Biological Process GO:0071639 positive regulation of monocyte chemotactic protein-1 production
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:0002539 prostaglandin production involved in inflammatory response
Biological Process GO:0009749 response to glucose

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.