Search Results
Overview
| Uniprot ID | P49914 |
|---|---|
| Protein Name | 5-formyltetrahydrofolate cyclo-ligase |
| Gene Name | MTHFS |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | AAAVSSAKRSLRGEL |
| 150 | GNRLGRGKGYYDAYL |
| 39 | QSRVLSQKVIAHSEY |
Function
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate
Protein Sequence
10
MAAAAVSSAK
20
RSLRGELKQR
30
LRAMSAEERL
40
RQSRVLSQKV
50
IAHSEYQKSK
60
RISIFLSMQD
70
EIETEEIIKD
80
IFQRGKICFI
90
PRYRFQSNHM
100
DMVRIESPEE
110
ISLLPKTSWN
120
IPQPGEGDVR
130
EEALSTGGLD
140
LIFMPGLGFD
150
KHGNRLGRGK
160
GYYDAYLKRC
170
LQHQEVKPYT
180
LALAFKEQIC
190
LQVPVNENDM
200
KVDEVLYEDS
STA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0030272 | 5-formyltetrahydrofolate cyclo-ligase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005542 | folic acid binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0046657 | folic acid catabolic process |
| Biological Process | GO:0046655 | folic acid metabolic process |
| Biological Process | GO:0009396 | folic acid-containing compound biosynthetic process |
| Biological Process | GO:0015942 | formate metabolic process |
| Biological Process | GO:0006536 | glutamate metabolic process |
| Biological Process | GO:0035999 | tetrahydrofolate interconversion |
| Biological Process | GO:0046653 | tetrahydrofolate metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.