Search Results
Overview
| Uniprot ID | P49918 |
|---|---|
| Protein Name | Cyclin-dependent kinase inhibitor 1C |
| Gene Name | CDKN1C |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 266 | ANGAAIKKLSGPLIS |
Function
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life
Protein Sequence
10
MSDASLRSTS
20
TMERLVARGT
30
FPVLVRTSAC
40
RSLFGPVDHE
50
ELSRELQARL
60
AELNAEDQNR
70
WDYDFQQDMP
80
LRGPGRLQWT
90
EVDSDSVPAF
100
YRETVQVGRC
110
RLLLAPRPVA
120
VAVAVSPPLE
130
PAAESLDGLE
140
EAPEQLPSVP
150
VPAPASTPPP
160
VPVLAPAPAP
170
APAPVAAPVA
180
APVAVAVLAP
190
APAPAPAPAP
200
APAPVAAPAP
210
APAPAPAPAP
220
APAPAPDAAP
230
QESAEQGANQ
240
GQRGQEPLAD
250
QLHSGISGRP
260
AAGTAAASAN
270
GAAIKKLSGP
280
LISDFFAKRK
290
RSAPEKSSGD
300
VPAPCPSPSA
310
APGVGSVEQT
PRKRLR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| Molecular Function | GO:0140678 | molecular function inhibitor activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0050680 | negative regulation of epithelial cell proliferation |
| Biological Process | GO:0045930 | negative regulation of mitotic cell cycle |
| Biological Process | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
Reference
PMID: N/A