Search Results
Overview
| Uniprot ID | P49961 |
|---|---|
| Protein Name | Ectonucleoside triphosphate diphosphohydrolase 1 |
| Gene Name | ENTPD1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 288 | PCFHPGYKKVVNVSD |
Function
Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (Probable) (PubMed:8529670, PubMed:8626624, PubMed:8955160, PubMed:8996251). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (Probable) (PubMed:8529670, PubMed:8626624, PubMed:8955160, PubMed:8996251). This activity contributes to the regulation of extracellular levels of nucleotides (Probable) (PubMed:8529670, PubMed:8626624, PubMed:8955160, PubMed:8996251). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow (PubMed:8955160, PubMed:8996251)
Protein Sequence
10
MEDTKESNVK
20
TFCSKNILAI
30
LGFSSIIAVI
40
ALLAVGLTQN
50
KALPENVKYG
60
IVLDAGSSHT
70
SLYIYKWPAE
80
KENDTGVVHQ
90
VEECRVKGPG
100
ISKFVQKVNE
110
IGIYLTDCME
120
RAREVIPRSQ
130
HQETPVYLGA
140
TAGMRLLRME
150
SEELADRVLD
160
VVERSLSNYP
170
FDFQGARIIT
180
GQEEGAYGWI
190
TINYLLGKFS
200
QKTRWFSIVP
210
YETNNQETFG
220
ALDLGGASTQ
230
VTFVPQNQTI
240
ESPDNALQFR
250
LYGKDYNVYT
260
HSFLCYGKDQ
270
ALWQKLAKDI
280
QVASNEILRD
290
PCFHPGYKKV
300
VNVSDLYKTP
310
CTKRFEMTLP
320
FQQFEIQGIG
330
NYQQCHQSIL
340
ELFNTSYCPY
350
SQCAFNGIFL
360
PPLQGDFGAF
370
SAFYFVMKFL
380
NLTSEKVSQE
390
KVTEMMKKFC
400
AQPWEEIKTS
410
YAGVKEKYLS
420
EYCFSGTYIL
430
SLLLQGYHFT
440
ADSWEHIHFI
450
GKIQGSDAGW
460
TLGYMLNLTN
470
MIPAEQPLST
480
PLSHSTYVFL
490
MVLFSLVLFT
500
VAIIGLLIFH
510
KPSYFWKDMV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0103023 | ITPase activity |
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0043262 | ADP phosphatase activity |
| Molecular Function | GO:0004050 | apyrase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0036384 | CDP phosphatase activity |
| Molecular Function | GO:0043273 | CTPase activity |
| Molecular Function | GO:0004382 | GDP phosphatase activity |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:1990003 | IDP phosphatase activity |
| Molecular Function | GO:0017110 | nucleoside diphosphate phosphatase activity |
| Molecular Function | GO:0017111 | ribonucleoside triphosphate phosphatase activity |
| Molecular Function | GO:0045134 | UDP phosphatase activity |
| Biological Process | GO:0046032 | ADP catabolic process |
| Biological Process | GO:0007596 | blood coagulation |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0009134 | nucleoside diphosphate catabolic process |
| Biological Process | GO:0070527 | platelet aggregation |
Reference
PMID: N/A