Search Results
Overview
| Uniprot ID | P50053 |
|---|---|
| Protein Name | Ketohexokinase |
| Gene Name | KHK |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 148 | RNASEQVKMLQRIDA |
| 165 | TRQPPEQKIRVSVEV |
| 174 | RVSVEVEKPREELFQ |
| 197 | FVSKDVAKHLGFQSA |
| 25 | SLVDKYPKEDSEIRC |
| 287 | FGCQVAGKKCGLQGF |
Function
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate
Protein Sequence
10
MEEKQILCVG
20
LVVLDVISLV
30
DKYPKEDSEI
40
RCLSQRWQRG
50
GNASNSCTVL
60
SLLGAPCAFM
70
GSMAPGHVAD
80
FLVADFRRRG
90
VDVSQVAWQS
100
KGDTPSSCCI
110
INNSNGNRTI
120
VLHDTSLPDV
130
SATDFEKVDL
140
TQFKWIHIEG
150
RNASEQVKML
160
QRIDAHNTRQ
170
PPEQKIRVSV
180
EVEKPREELF
190
QLFGYGDVVF
200
VSKDVAKHLG
210
FQSAEEALRG
220
LYGRVRKGAV
230
LVCAWAEEGA
240
DALGPDGKLL
250
HSDAFPPPRV
260
VDTLGAGDTF
270
NASVIFSLSQ
280
GRSVQEALRF
290
GCQVAGKKCG
LQGFDGIV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0070061 | fructose binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004454 | ketohexokinase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0006000 | fructose metabolic process |
| Biological Process | GO:0070873 | regulation of glycogen metabolic process |
| Biological Process | GO:0032868 | response to insulin |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.