Search Results
Overview
| Uniprot ID | P50135 |
|---|---|
| Protein Name | Histamine N-methyltransferase |
| Gene Name | HNMT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | KYKELVAKTSNLENV |
| 112 | TSNLENVKFAWHKET |
| 117 | NVKFAWHKETSSEYQ |
| 14 | SLFSDHGKYVESFRR |
| 264 | DLRAELGKDLQEPEF |
| 274 | QEPEFSAKKEGKVLF |
| 38 | CMQEFMDKKLPGIIG |
| 39 | MQEFMDKKLPGIIGR |
| 99 | AEQIAKYKELVAKTS |
Function
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine
Protein Sequence
10
MASSMRSLFS
20
DHGKYVESFR
30
RFLNHSTEHQ
40
CMQEFMDKKL
50
PGIIGRIGDT
60
KSEIKILSIG
70
GGAGEIDLQI
80
LSKVQAQYPG
90
VCINNEVVEP
100
SAEQIAKYKE
110
LVAKTSNLEN
120
VKFAWHKETS
130
SEYQSRMLEK
140
KELQKWDFIH
150
MIQMLYYVKD
160
IPATLKFFHS
170
LLGTNAKMLI
180
IVVSGSSGWD
190
KLWKKYGSRF
200
PQDDLCQYIT
210
SDDLTQMLDN
220
LGLKYECYDL
230
LSTMDISDCF
240
IDGNENGDLL
250
WDFLTETCNF
260
NATAPPDLRA
270
ELGKDLQEPE
280
FSAKKEGKVL
290
FNNTLSFIVI
EA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0046539 | histamine N-methyltransferase activity |
| Biological Process | GO:0001695 | histamine catabolic process |
| Biological Process | GO:0001692 | histamine metabolic process |
| Biological Process | GO:0006548 | L-histidine catabolic process |
| Biological Process | GO:0032259 | methylation |
| Biological Process | GO:0007585 | respiratory gaseous exchange by respiratory system |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.