Search Results

Overview

Uniprot IDP50213
Protein NameIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Gene NameIDH3A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
177 LITEGASKRIAEFAF
336 AACFATIKDGKSLTK
339 FATIKDGKSLTKDLG
343 KDGKSLTKDLGGNAK
350 KDLGGNAKCSDFTEE
58 MKIFDAAKAPIQWEE
77 AIQGPGGKWMIPSEA

Function

Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers

Protein Sequence

10 MAGPAWISKV 20 SRLLGAFHNP 30 KQVTRGFTGG 40 VQTVTLIPGD 50 GIGPEISAAV 60 MKIFDAAKAP 70 IQWEERNVTA 80 IQGPGGKWMI 90 PSEAKESMDK 100 NKMGLKGPLK 110 TPIAAGHPSM 120 NLLLRKTFDL 130 YANVRPCVSI 140 EGYKTPYTDV 150 NIVTIRENTE 160 GEYSGIEHVI 170 VDGVVQSIKL 180 ITEGASKRIA 190 EFAFEYARNN 200 HRSNVTAVHK 210 ANIMRMSDGL 220 FLQKCREVAE 230 SCKDIKFNEM 240 YLDTVCLNMV 250 QDPSQFDVLV 260 MPNLYGDILS 270 DLCAGLIGGL 280 GVTPSGNIGA 290 NGVAIFESVH 300 GTAPDIAGKD 310 MANPTALLLS 320 AVMMLRHMGL 330 FDHAARIEAA 340 CFATIKDGKS 350 LTKDLGGNAK 360 CSDFTEEICR RVKDLD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0045242 isocitrate dehydrogenase complex (NAD+)
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Molecular Function GO:0004449 isocitrate dehydrogenase (NAD+) activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0051287 NAD binding
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0006102 isocitrate metabolic process
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.