Overview
| Uniprot ID | P50225 |
|---|
| Protein Name | Sulfotransferase 1A1 |
|---|
| Gene Name | SULT1A1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 106 |
TPAPRLLKTHLPLAL |
| 122 |
PQTLLDQKVKVVYVA |
| 124 |
TLLDQKVKVVYVARN |
| 258 |
SISPFMRKGMAGDWK |
| 97 |
PSGMETLKDTPAPRL |
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine group. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones (PubMed:12471039, PubMed:16221673, PubMed:21723874, PubMed:22069470, PubMed:7834621). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:7834621). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440). Catalyzes the sulfate conjugation of dopamine (PubMed:8093002). Catalyzes the sulfation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine), T3 (3,5,3'-triiodothyronine), rT3 (3,3',5'-triiodothyronine) and 3,3'-T2 (3,3'-diiodothyronine), with a substrate preference of 3,3'-T2 > rT3 > T3 > T4 (PubMed:10199779)
Protein Sequence
10
MELIQDTSRP
20
PLEYVKGVPL
30
IKYFAEALGP
40
LQSFQARPDD
50
LLISTYPKSG
60
TTWVSQILDM
70
IYQGGDLEKC
80
HRAPIFMRVP
90
FLEFKAPGIP
100
SGMETLKDTP
110
APRLLKTHLP
120
LALLPQTLLD
130
QKVKVVYVAR
140
NAKDVAVSYY
150
HFYHMAKVHP
160
EPGTWDSFLE
170
KFMVGEVSYG
180
SWYQHVQEWW
190
ELSRTHPVLY
200
LFYEDMKENP
210
KREIQKILEF
220
VGRSLPEETV
230
DFVVQHTSFK
240
EMKKNPMTNY
250
TTVPQEFMDH
260
SISPFMRKGM
270
AGDWKTTFTV
280
AQNERFDADY
290
AEKMAGCSLS
FRSEL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0050656 |
3'-phosphoadenosine 5'-phosphosulfate binding |
| Molecular Function |
GO:0004062 |
aryl sulfotransferase activity |
| Molecular Function |
GO:0047894 |
flavonol 3-sulfotransferase activity |
| Molecular Function |
GO:0050294 |
steroid sulfotransferase activity |
| Molecular Function |
GO:0008146 |
sulfotransferase activity |
| Biological Process |
GO:0050427 |
3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| Biological Process |
GO:0009308 |
amine metabolic process |
| Biological Process |
GO:0042420 |
dopamine catabolic process |
| Biological Process |
GO:0008210 |
estrogen metabolic process |
| Biological Process |
GO:0006068 |
ethanol catabolic process |
| Biological Process |
GO:0009812 |
flavonoid metabolic process |
| Biological Process |
GO:0051923 |
sulfation |
| Biological Process |
GO:0042403 |
thyroid hormone metabolic process |
| Biological Process |
GO:0006805 |
xenobiotic metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.