Search Results
Overview
| Uniprot ID | P50226 |
|---|---|
| Protein Name | Sulfotransferase 1A2 |
| Gene Name | SULT1A2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | TPAPRLLKTHLPLAL |
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk
Protein Sequence
10
MELIQDISRP
20
PLEYVKGVPL
30
IKYFAEALGP
40
LQSFQARPDD
50
LLISTYPKSG
60
TTWVSQILDM
70
IYQGGDLEKC
80
HRAPIFMRVP
90
FLEFKVPGIP
100
SGMETLKNTP
110
APRLLKTHLP
120
LALLPQTLLD
130
QKVKVVYVAR
140
NAKDVAVSYY
150
HFYHMAKVYP
160
HPGTWESFLE
170
KFMAGEVSYG
180
SWYQHVQEWW
190
ELSRTHPVLY
200
LFYEDMKENP
210
KREIQKILEF
220
VGRSLPEETV
230
DLMVEHTSFK
240
EMKKNPMTNY
250
TTVRREFMDH
260
SISPFMRKGM
270
AGDWKTTFTV
280
AQNERFDADY
290
AKKMAGCSLS
FRSEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004062 | aryl sulfotransferase activity |
| Molecular Function | GO:0047894 | flavonol 3-sulfotransferase activity |
| Molecular Function | GO:0008146 | sulfotransferase activity |
| Biological Process | GO:0050427 | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| Biological Process | GO:0009309 | amine biosynthetic process |
| Biological Process | GO:0006584 | catecholamine metabolic process |
| Biological Process | GO:0006068 | ethanol catabolic process |
| Biological Process | GO:0018958 | phenol-containing compound metabolic process |
| Biological Process | GO:0008202 | steroid metabolic process |
| Biological Process | GO:0051923 | sulfation |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.