Search Results

Overview

Uniprot IDP50395
Protein NameRab GDP dissociation inhibitor beta
Gene NameGDI2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
112 TEGSFVYKGGKIYKV
142 FEKRRFRKFLVYVAN
164 TFEGIDPKKTTMRDV
165 FEGIDPKKTTMRDVY
210 YETINRIKLYSESLA
269 NGKVIGVKSEGEIAR
288 ICDPSYVKDRVEKVG
29 IMSVNGKKVLHMDRN
293 YVKDRVEKVGQVIRV
329 PQNQVNRKSDIYVCM
418 ETTCDDIKNIYKRMT

Function

GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027)

Protein Sequence

10 MNEEYDVIVL 20 GTGLTECILS 30 GIMSVNGKKV 40 LHMDRNPYYG 50 GESASITPLE 60 DLYKRFKIPG 70 SPPESMGRGR 80 DWNVDLIPKF 90 LMANGQLVKM 100 LLYTEVTRYL 110 DFKVTEGSFV 120 YKGGKIYKVP 130 STEAEALASS 140 LMGLFEKRRF 150 RKFLVYVANF 160 DEKDPRTFEG 170 IDPKKTTMRD 180 VYKKFDLGQD 190 VIDFTGHALA 200 LYRTDDYLDQ 210 PCYETINRIK 220 LYSESLARYG 230 KSPYLYPLYG 240 LGELPQGFAR 250 LSAIYGGTYM 260 LNKPIEEIIV 270 QNGKVIGVKS 280 EGEIARCKQL 290 ICDPSYVKDR 300 VEKVGQVIRV 310 ICILSHPIKN 320 TNDANSCQII 330 IPQNQVNRKS 340 DIYVCMISFA 350 HNVAAQGKYI 360 AIVSTTVETK 370 EPEKEIRPAL 380 ELLEPIEQKF 390 VSISDLLVPK 400 DLGTESQIFI 410 SRTYDATTHF 420 ETTCDDIKNI 430 YKRMTGSEFD 440 FEEMKRKKND IYGED

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035578 azurophil granule lumen
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0016020 membrane
Cellular Component GO:0034774 secretory granule lumen
Cellular Component GO:0045202 synapse
Cellular Component GO:0031982 vesicle
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005093 Rab GDP-dissociation inhibitor activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:1902018 negative regulation of cilium assembly
Biological Process GO:1903565 negative regulation of protein localization to cilium
Biological Process GO:0015031 protein transport
Biological Process GO:0007165 signal transduction
Biological Process GO:0007264 small GTPase-mediated signal transduction
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.