Search Results
Overview
| Uniprot ID | P50398 |
|---|---|
| Protein Name | Rab GDP dissociation inhibitor alpha |
| Gene Name | Gdi1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 112 | VEGSFVYKGGKIYKV |
| 269 | NGKVVGVKSEGEVAR |
| 29 | IMSVNGKKVLHMDRN |
| 293 | YIPDRVRKAGQVIRI |
| 435 | AFDFENMKRKQNDVF |
| 437 | DFENMKRKQNDVFGE |
Function
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes
Protein Sequence
10
MDEEYDVIVL
20
GTGLTECILS
30
GIMSVNGKKV
40
LHMDRNPYYG
50
GESSSITPLE
60
ELYKRFQLLE
70
GPPESMGRGR
80
DWNVDLIPKF
90
LMANGQLVKM
100
LLYTEVTRYL
110
DFKVVEGSFV
120
YKGGKIYKVP
130
STETEALASN
140
LMGMFEKRRF
150
RKFLVFVANF
160
DENDPKTFEG
170
VDPQTTSMRD
180
VYRKFDLGQD
190
VIDFTGHALA
200
LYRTDDYLDQ
210
PCLETINRIK
220
LYSESLARYG
230
KSPYLYPLYG
240
LGELPQGFAR
250
LSAIYGGTYM
260
LNKPVDDIIM
270
ENGKVVGVKS
280
EGEVARCKQL
290
ICDPSYIPDR
300
VRKAGQVIRI
310
ICILSHPIKN
320
TNDANSCQII
330
IPQNQVNRKS
340
DIYVCMISYA
350
HNVAAQGKYI
360
AIASTTVETA
370
EPEKEVEPAL
380
ELLEPIDQKF
390
VAISDLYEPI
400
DDGSESQVFC
410
SCSYDATTHF
420
ETTCNDIKDI
430
YKRMAGSAFD
440
FENMKRKQND
VFGEADQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0099523 | presynaptic cytosol |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0005092 | GDP-dissociation inhibitor activity |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0005093 | Rab GDP-dissociation inhibitor activity |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0050771 | negative regulation of axonogenesis |
| Biological Process | GO:0090315 | negative regulation of protein targeting to membrane |
| Biological Process | GO:0045773 | positive regulation of axon extension |
| Biological Process | GO:0034123 | positive regulation of toll-like receptor signaling pathway |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0032482 | Rab protein signal transduction |
| Biological Process | GO:0051592 | response to calcium ion |
| Biological Process | GO:0016192 | vesicle-mediated transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.