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Overview

Uniprot IDP50399
Protein NameRab GDP dissociation inhibitor beta
Gene NameGdi2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
112 IEGSFVYKGGKIYKV
164 TFEGVDPKKTSMRDV
210 CETINRIKLYSESLA
269 NGKVVGVKSEGEIAR
418 ETTCDDIKDIYKRMT

Function

GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A

Protein Sequence

10 MNEEYDVIVL 20 GTGLTECILS 30 GIMSVNGKKV 40 LHMDQNPYYG 50 GESASITPLE 60 DLYKRFKLPG 70 QPPASMGRGR 80 DWNVDLIPKF 90 LMANGQLVKM 100 LLFTEVTRYM 110 DFKVIEGSFV 120 YKGGKIYKVP 130 STEAEALASS 140 LMGLFEKRRF 150 RKFLVYVANF 160 DEKDPRTFEG 170 VDPKKTSMRD 180 VYKKFDLGQD 190 VIDFTGHSLA 200 LYRTDDYLDQ 210 PCCETINRIK 220 LYSESLARYG 230 KSPYLYPLYG 240 LGELPQGFAR 250 LSAIYGGTYM 260 LNKPIEEIIV 270 QNGKVVGVKS 280 EGEIARCKQL 290 ICDPSYVKDR 300 VEKVGQVIRV 310 ICILSHPIKN 320 TNDANSCQII 330 IPQNQVNRKS 340 DIYVCMISFA 350 HNVAAQGKYI 360 AIVSTTVETK 370 EPEKEIRPAL 380 ELLEPIEQKF 390 VSISDLFVPK 400 DLGTDSQIFI 410 SRAYDATTHF 420 ETTCDDIKDI 430 YKRMTGSEFD 440 FEEMKRKKND IYGED

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0016020 membrane
Cellular Component GO:0045202 synapse
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005093 Rab GDP-dissociation inhibitor activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:1902018 negative regulation of cilium assembly
Biological Process GO:1903565 negative regulation of protein localization to cilium
Biological Process GO:0015031 protein transport
Biological Process GO:0007264 small GTPase-mediated signal transduction
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.