Overview
| Uniprot ID | P50408 |
|---|
| Protein Name | V-type proton ATPase subunit F |
|---|
| Gene Name | Atp6v1f |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 102 |
EHPYDAAKDSILRRA |
| 110 |
DSILRRAKGMFTAED |
Function
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32165585). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity)
Protein Sequence
10
MAGRGKLIAV
20
IGDEDTVTGF
30
LLGGIGELNK
40
NRHPNFLVVE
50
KDTTINEIED
60
TFRQFLNRDD
70
IGIILINQYI
80
AEMVRHALDA
90
HQRSIPAVLE
100
IPSKEHPYDA
110
AKDSILRRAK
GMFTAEDLR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030665 |
clathrin-coated vesicle membrane |
| Cellular Component |
GO:0098850 |
extrinsic component of synaptic vesicle membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0033176 |
proton-transporting V-type ATPase complex |
| Cellular Component |
GO:0016471 |
vacuolar proton-transporting V-type ATPase complex |
| Cellular Component |
GO:0000221 |
vacuolar proton-transporting V-type ATPase, V1 domain |
| Molecular Function |
GO:0046961 |
proton-transporting ATPase activity, rotational mechanism |
| Biological Process |
GO:0097401 |
synaptic vesicle lumen acidification |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.