Overview
| Uniprot ID | P50416 |
|---|
| Protein Name | Carnitine O-palmitoyltransferase 1, liver isoform |
|---|
| Gene Name | CPT1A |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 180 |
RLPVPAVKDTVNRYL |
| 285 |
AILLYRRKLDREEIK |
| 40 |
LSGLHSWKKKFIRFK |
Function
Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:11350182, PubMed:14517221, PubMed:16651524, PubMed:9691089). Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (PubMed:29425493). Plays an important role in hepatic triglyceride metabolism (By similarity). Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (PubMed:38016475). Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (By similarity)
Protein Sequence
10
MAEAHQAVAF
20
QFTVTPDGID
30
LRLSHEALRQ
40
IYLSGLHSWK
50
KKFIRFKNGI
60
ITGVYPASPS
70
SWLIVVVGVM
80
TTMYAKIDPS
90
LGIIAKINRT
100
LETANCMSSQ
110
TKNVVSGVLF
120
GTGLWVALIV
130
TMRYSLKVLL
140
SYHGWMFTEH
150
GKMSRATKIW
160
MGMVKIFSGR
170
KPMLYSFQTS
180
LPRLPVPAVK
190
DTVNRYLQSV
200
RPLMKEEDFK
210
RMTALAQDFA
220
VGLGPRLQWY
230
LKLKSWWATN
240
YVSDWWEEYI
250
YLRGRGPLMV
260
NSNYYAMDLL
270
YILPTHIQAA
280
RAGNAIHAIL
290
LYRRKLDREE
300
IKPIRLLGST
310
IPLCSAQWER
320
MFNTSRIPGE
330
ETDTIQHMRD
340
SKHIVVYHRG
350
RYFKVWLYHD
360
GRLLKPREME
370
QQMQRILDNT
380
SEPQPGEARL
390
AALTAGDRVP
400
WARCRQAYFG
410
RGKNKQSLDA
420
VEKAAFFVTL
430
DETEEGYRSE
440
DPDTSMDSYA
450
KSLLHGRCYD
460
RWFDKSFTFV
470
VFKNGKMGLN
480
AEHSWADAPI
490
VAHLWEYVMS
500
IDSLQLGYAE
510
DGHCKGDINP
520
NIPYPTRLQW
530
DIPGECQEVI
540
ETSLNTANLL
550
ANDVDFHSFP
560
FVAFGKGIIK
570
KCRTSPDAFV
580
QLALQLAHYK
590
DMGKFCLTYE
600
ASMTRLFREG
610
RTETVRSCTT
620
ESCDFVRAMV
630
DPAQTVEQRL
640
KLFKLASEKH
650
QHMYRLAMTG
660
SGIDRHLFCL
670
YVVSKYLAVE
680
SPFLKEVLSE
690
PWRLSTSQTP
700
QQQVELFDLE
710
NNPEYVSSGG
720
GFGPVADDGY
730
GVSYILVGEN
740
LINFHISSKF
750
SCPETDSHRF
760
GRHLKEAMTD
770
IITLFGLSSN
SKK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0004095 |
carnitine O-palmitoyltransferase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Biological Process |
GO:0009437 |
carnitine metabolic process |
| Biological Process |
GO:0006853 |
carnitine shuttle |
| Biological Process |
GO:0071398 |
cellular response to fatty acid |
| Biological Process |
GO:0042755 |
eating behavior |
| Biological Process |
GO:0030855 |
epithelial cell differentiation |
| Biological Process |
GO:0006635 |
fatty acid beta-oxidation |
| Biological Process |
GO:0006631 |
fatty acid metabolic process |
| Biological Process |
GO:0006006 |
glucose metabolic process |
| Biological Process |
GO:0097421 |
liver regeneration |
| Biological Process |
GO:0001676 |
long-chain fatty acid metabolic process |
| Biological Process |
GO:0032000 |
positive regulation of fatty acid beta-oxidation |
| Biological Process |
GO:0045089 |
positive regulation of innate immune response |
| Biological Process |
GO:0050796 |
regulation of insulin secretion |
| Biological Process |
GO:0043279 |
response to alkaloid |
| Biological Process |
GO:0045471 |
response to ethanol |
| Biological Process |
GO:0001666 |
response to hypoxia |
| Biological Process |
GO:0007584 |
response to nutrient |
| Biological Process |
GO:1904772 |
response to tetrachloromethane |
| Biological Process |
GO:0009410 |
response to xenobiotic stimulus |
| Biological Process |
GO:0006641 |
triglyceride metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.