Search Results
Overview
| Uniprot ID | P50452 |
|---|---|
| Protein Name | Serpin B8 |
| Gene Name | SERPINB8 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 263 | SEKLTKSKVQVFLPR |
Function
Has an important role in epithelial desmosome-mediated cell-cell adhesion
Protein Sequence
10
MDDLCEANGT
20
FAISLFKILG
30
EEDNSRNVFF
40
SPMSISSALA
50
MVFMGAKGST
60
AAQMSQALCL
70
YKDGDIHRGF
80
QSLLSEVNRT
90
GTQYLLRTAN
100
RLFGEKTCDF
110
LPDFKEYCQK
120
FYQAELEELS
130
FAEDTEECRK
140
HINDWVAEKT
150
EGKISEVLDA
160
GTVDPLTKLV
170
LVNAIYFKGK
180
WNEQFDRKYT
190
RGMLFKTNEE
200
KKTVQMMFKE
210
AKFKMGYADE
220
VHTQVLELPY
230
VEEELSMVIL
240
LPDDNTDLAV
250
VEKALTYEKF
260
KAWTNSEKLT
270
KSKVQVFLPR
280
LKLEESYDLE
290
PFLRRLGMID
300
AFDEAKADFS
310
GMSTEKNVPL
320
SKVAHKCFVE
330
VNEEGTEAAA
340
ATAVVRNSRC
350
SRMEPRFCAD
360
HPFLFFIRHH
370
KTNCILFCGR
FSSP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Biological Process | GO:0090136 | epithelial cell-cell adhesion |
| Biological Process | GO:0010951 | negative regulation of endopeptidase activity |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.