Search Results
Overview
| Uniprot ID | P50454 |
|---|---|
| Protein Name | Serpin H1 |
| Gene Name | SERPINH1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 287 | RLEKLLTKEQLKIWM |
| 300 | WMGKMQKKAVAISLP |
| 332 | GLTEAIDKNKADLSR |
Function
Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen
Protein Sequence
10
MRSLLLLSAF
20
CLLEAALAAE
30
VKKPAAAAAP
40
GTAEKLSPKA
50
ATLAERSAGL
60
AFSLYQAMAK
70
DQAVENILVS
80
PVVVASSLGL
90
VSLGGKATTA
100
SQAKAVLSAE
110
QLRDEEVHAG
120
LGELLRSLSN
130
STARNVTWKL
140
GSRLYGPSSV
150
SFADDFVRSS
160
KQHYNCEHSK
170
INFRDKRSAL
180
QSINEWAAQT
190
TDGKLPEVTK
200
DVERTDGALL
210
VNAMFFKPHW
220
DEKFHHKMVD
230
NRGFMVTRSY
240
TVGVMMMHRT
250
GLYNYYDDEK
260
EKLQIVEMPL
270
AHKLSSLIIL
280
MPHHVEPLER
290
LEKLLTKEQL
300
KIWMGKMQKK
310
AVAISLPKGV
320
VEVTHDLQKH
330
LAGLGLTEAI
340
DKNKADLSRM
350
SGKKDLYLAS
360
VFHATAFELD
370
TDGNPFDQDI
380
YGREELRSPK
390
LFYADHPFIF
400
LVRDTQSGSL
410
LFIGRLVRPK
GDKMRDEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0045121 | membrane raft |
| Molecular Function | GO:0005518 | collagen binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0030199 | collagen fibril organization |
| Biological Process | GO:0006986 | response to unfolded protein |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.