Search Results

Overview

Uniprot IDP50462
Protein NameCysteine and glycine-rich protein 3
Gene NameCsrp3
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
109 ATTSNPSKFSAKFGE
113 NPSKFSAKFGESEKC
119 AKFGESEKCPRCGKS
125 EKCPRCGKSVYAAEK
132 KSVYAAEKVMGGGKP
138 EKVMGGGKPWHKTCF
162 ESTNVTDKDGELYCK
42 FHCMACRKALDSTTV
59 HESEIYCKVCYGRRY
9 PNWGGGAKCGACEKT

Function

Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (PubMed:15665106, PubMed:9039266). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly. Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (By similarity). In vitro can inhibit PKC/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (PubMed:27353086)

Protein Sequence

10 MPNWGGGAKC 20 GACEKTVYHA 30 EEIQCNGRSF 40 HKTCFHCMAC 50 RKALDSTTVA 60 AHESEIYCKV 70 CYGRRYGPKG 80 IGFGQGAGCL 90 STDTGEHLGL 100 QFQQSPKPAR 110 AATTSNPSKF 120 SAKFGESEKC 130 PRCGKSVYAA 140 EKVMGGGKPW 150 HKTCFRCAIC 160 GKSLESTNVT 170 DKDGELYCKV 180 CYAKNFGPTG 190 IGFGGLTQQV EKKE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003779 actin binding
Molecular Function GO:0042805 actinin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0043426 MRF binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0008307 structural constituent of muscle
Molecular Function GO:0031433 telethonin binding
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0003300 cardiac muscle hypertrophy
Biological Process GO:0048738 cardiac muscle tissue development
Biological Process GO:0055003 cardiac myofibril assembly
Biological Process GO:0035995 detection of muscle stretch
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0072594 establishment of protein localization to organelle
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0007507 heart development
Biological Process GO:0006954 inflammatory response
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0006874 intracellular calcium ion homeostasis
Biological Process GO:0007517 muscle organ development
Biological Process GO:0060537 muscle tissue development
Biological Process GO:1903919 negative regulation of actin filament severing
Biological Process GO:0045662 negative regulation of myoblast differentiation
Biological Process GO:0141212 phospholipase C/protein kinase C signal transduction
Biological Process GO:1903920 positive regulation of actin filament severing
Biological Process GO:0045663 positive regulation of myoblast differentiation
Biological Process GO:0010831 positive regulation of myotube differentiation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:1903076 regulation of protein localization to plasma membrane
Biological Process GO:0002026 regulation of the force of heart contraction
Biological Process GO:0045214 sarcomere organization
Biological Process GO:0033292 T-tubule organization

Reference

[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.