Search Results
Overview
| Uniprot ID | P50502 |
|---|---|
| Protein Name | Hsc70-interacting protein |
| Gene Name | ST13 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 118 | MDQANDKKVAAIEAL |
| 153 | RLAILYAKRASVFVK |
| 160 | KRASVFVKLQKPNAA |
Function
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity)
Protein Sequence
10
MDPRKVNELR
20
AFVKMCKQDP
30
SVLHTEEMRF
40
LREWVESMGG
50
KVPPATQKAK
60
SEENTKEEKP
70
DSKKVEEDLK
80
ADEPSSEESD
90
LEIDKEGVIE
100
PDTDAPQEMG
110
DENAEITEEM
120
MDQANDKKVA
130
AIEALNDGEL
140
QKAIDLFTDA
150
IKLNPRLAIL
160
YAKRASVFVK
170
LQKPNAAIRD
180
CDRAIEINPD
190
SAQPYKWRGK
200
AHRLLGHWEE
210
AAHDLALACK
220
LDYDEDASAM
230
LKEVQPRAQK
240
IAEHRRKYER
250
KREEREIKER
260
IERVKKAREE
270
HERAQREEEA
280
RRQSGAQYGS
290
FPGGFPGGMP
300
GNFPGGMPGM
310
GGGMPGMAGM
320
PGLNEILSDP
330
EVLAAMQDPE
340
VMVAFQDVAQ
350
NPANMSKYQS
360
NPKVMNLISK
LSAKFGGQA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0006457 | protein folding |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.