Search Results
Overview
| Uniprot ID | P50503 |
|---|---|
| Protein Name | Hsc70-interacting protein |
| Gene Name | St13 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 117 | MDEANEKKGAAIDAL |
| 152 | RLAILYAKRASVFVK |
Function
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins
Protein Sequence
10
MDPRKVSELR
20
AFVKMCRQDP
30
SVLHTEEMRF
40
LREWVESMGG
50
KVPPATHKAK
60
SEENTKEEKR
70
DKTTEDNIKT
80
EEPSSEESDL
90
EIDNEGVIEA
100
DTDAPQEMGD
110
ENAEITEAMM
120
DEANEKKGAA
130
IDALNDGELQ
140
KAIDLFTDAI
150
KLNPRLAILY
160
AKRASVFVKL
170
QKPNAAIRDC
180
DRAIEINPDS
190
AQPYKWRGKA
200
HRLLGHWEEA
210
ARDLALACKL
220
DYDEDASAML
230
REVQPRAQKI
240
AEHRRKYERK
250
REEREIKERI
260
ERVKKAREEH
270
EKAQREEEAR
280
RQSGSQFGSF
290
PGGFPGGMPG
300
NFPGGMPGMG
310
GAMPGMAGMP
320
GLNEILSDPE
330
VLAAMQDPEV
340
MVAFQDVAQN
350
PSNMSKYQNN
360
PKVMNLISKL
SAKFGGHS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0019904 | protein domain specific binding |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0032564 | dATP binding |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0061084 | negative regulation of protein refolding |
| Biological Process | GO:1903334 | positive regulation of protein folding |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0009617 | response to bacterium |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.