Search Results

Overview

Uniprot IDP50548
Protein NameETS domain-containing transcription factor ERF
Gene NameERF
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
378 SSSPFKFKLQPPPLG
394 RQRAAGEKAVAGADK
401 KAVAGADKSGGSAGG
481 ASQCMPLKLRFKRRW

Function

Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity)

Protein Sequence

10 MKTPADTGFA 20 FPDWAYKPES 30 SPGSRQIQLW 40 HFILELLRKE 50 EYQGVIAWQG 60 DYGEFVIKDP 70 DEVARLWGVR 80 KCKPQMNYDK 90 LSRALRYYYN 100 KRILHKTKGK 110 RFTYKFNFNK 120 LVLVNYPFID 130 VGLAGGAVPQ 140 SAPPVPSGGS 150 HFRFPPSTPS 160 EVLSPTEDPR 170 SPPACSSSSS 180 SLFSAVVARR 190 LGRGSVSDCS 200 DGTSELEEPL 210 GEDPRARPPG 220 PPDLGAFRGP 230 PLARLPHDPG 240 VFRVYPRPRG 250 GPEPLSPFPV 260 SPLAGPGSLL 270 PPQLSPALPM 280 TPTHLAYTPS 290 PTLSPMYPSG 300 GGGPSGSGGG 310 SHFSFSPEDM 320 KRYLQAHTQS 330 VYNYHLSPRA 340 FLHYPGLVVP 350 QPQRPDKCPL 360 PPMAPETPPV 370 PSSASSSSSS 380 SSSPFKFKLQ 390 PPPLGRRQRA 400 AGEKAVAGAD 410 KSGGSAGGLA 420 EGAGALAPPP 430 PPPQIKVEPI 440 SEGESEEVEV 450 TDISDEDEED 460 GEVFKTPRAP 470 PAPPKPEPGE 480 APGASQCMPL 490 KLRFKRRWSE 500 DCRLEGGGGP 510 AGGFEDEGED 520 KKVRGEGPGE 530 AGGPLTPRRV 540 SSDLQHATAQ LSLEHRDS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0043565 sequence-specific DNA binding
Biological Process GO:0030154 cell differentiation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.