Search Results
Overview
| Uniprot ID | P50554 |
|---|---|
| Protein Name | 4-aminobutyrate aminotransferase, mitochondrial |
| Gene Name | Abat |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 231 | CLATTHSKAIHKIDI |
| 318 | KLRDIARKHGCAFLV |
| 358 | DVMSFSKKMMTGGFF |
| 452 | PDEAIRNKLILIARN |
| 460 | LILIARNKGVVLGGC |
| 470 | VLGGCGDKSIRFRPT |
Function
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10447691). Can also convert delta-aminovalerate and beta-alanine (PubMed:10447691)
Protein Sequence
10
MAFLLTTRRL
20
VCSSQKNLHL
30
FTPGSRYISQ
40
AAAKVDFEFD
50
YDGPLMKTEV
60
PGPRSQELMK
70
QLNTIQNAEA
80
VHFFCNYEES
90
RGNYLVDVDG
100
NRMLDLYSQI
110
SSVPIGYNHP
120
ALAKLVQQPQ
130
NASTFINRPA
140
LGILPPENFV
150
DKLRESLMSV
160
APKGMCQLIT
170
MACGSCSNEN
180
AFKTIFMWYR
190
SKERGQRGFS
200
KEELETCMVN
210
QSPGCPDYSI
220
LSFMGAFHGR
230
TMGCLATTHS
240
KAIHKIDIPS
250
FDWPIAPFPR
260
LKYPLEEFVT
270
DNQQEEARCL
280
EEVEDLIVKY
290
RKKKRTVAGI
300
IVEPIQSEGG
310
DNHASDDFFR
320
KLRDIARKHG
330
CAFLVDEVQT
340
GGGCTGKFWA
350
HEHWGLDDPA
360
DVMSFSKKMM
370
TGGFFHKEEF
380
RPSAPYRIFN
390
TWLGDPSKNL
400
LLAEVINIIK
410
REDLLNNVAH
420
AGKTLLTGLL
430
DLQAQYPQFV
440
SRVRGRGTFC
450
SFDTPDEAIR
460
NKLILIARNK
470
GVVLGGCGDK
480
SIRFRPTLVF
490
RDHHAHLFLN
500
IFSGILADFK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0032144 | 4-aminobutyrate transaminase complex |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0047298 | (S)-3-amino-2-methylpropionate transaminase activity |
| Molecular Function | GO:0034386 | 4-aminobutyrate:2-oxoglutarate transaminase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0051536 | iron-sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Molecular Function | GO:0032145 | succinate-semialdehyde dehydrogenase binding |
| Biological Process | GO:0021549 | cerebellum development |
| Biological Process | GO:0007620 | copulation |
| Biological Process | GO:0035640 | exploration behavior |
| Biological Process | GO:0009449 | gamma-aminobutyric acid biosynthetic process |
| Biological Process | GO:0009450 | gamma-aminobutyric acid catabolic process |
| Biological Process | GO:0009448 | gamma-aminobutyric acid metabolic process |
| Biological Process | GO:0007626 | locomotory behavior |
| Biological Process | GO:0045776 | negative regulation of blood pressure |
| Biological Process | GO:0033602 | negative regulation of dopamine secretion |
| Biological Process | GO:0014053 | negative regulation of gamma-aminobutyric acid secretion |
| Biological Process | GO:0050877 | nervous system process |
| Biological Process | GO:1904450 | positive regulation of aspartate secretion |
| Biological Process | GO:0045964 | positive regulation of dopamine metabolic process |
| Biological Process | GO:0031652 | positive regulation of heat generation |
| Biological Process | GO:0097151 | positive regulation of inhibitory postsynaptic potential |
| Biological Process | GO:0032024 | positive regulation of insulin secretion |
| Biological Process | GO:1902722 | positive regulation of prolactin secretion |
| Biological Process | GO:0070474 | positive regulation of uterine smooth muscle contraction |
| Biological Process | GO:0042220 | response to cocaine |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0010039 | response to iron ion |
| Biological Process | GO:0035094 | response to nicotine |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.