Search Results

Overview

Uniprot IDP50570
Protein NameDynamin-2
Gene NameDNM2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
299 SLPALRSKLQSQLLS
393 REISYAIKNIHGVRT

Function

Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484)

Protein Sequence

10 MGNRGMEELI 20 PLVNKLQDAF 30 SSIGQSCHLD 40 LPQIAVVGGQ 50 SAGKSSVLEN 60 FVGRDFLPRG 70 SGIVTRRPLI 80 LQLIFSKTEH 90 AEFLHCKSKK 100 FTDFDEVRQE 110 IEAETDRVTG 120 TNKGISPVPI 130 NLRVYSPHVL 140 NLTLIDLPGI 150 TKVPVGDQPP 160 DIEYQIKDMI 170 LQFISRESSL 180 ILAVTPANMD 190 LANSDALKLA 200 KEVDPQGLRT 210 IGVITKLDLM 220 DEGTDARDVL 230 ENKLLPLRRG 240 YIGVVNRSQK 250 DIEGKKDIRA 260 ALAAERKFFL 270 SHPAYRHMAD 280 RMGTPHLQKT 290 LNQQLTNHIR 300 ESLPALRSKL 310 QSQLLSLEKE 320 VEEYKNFRPD 330 DPTRKTKALL 340 QMVQQFGVDF 350 EKRIEGSGDQ 360 VDTLELSGGA 370 RINRIFHERF 380 PFELVKMEFD 390 EKDLRREISY 400 AIKNIHGVRT 410 GLFTPDLAFE 420 AIVKKQVVKL 430 KEPCLKCVDL 440 VIQELINTVR 450 QCTSKLSSYP 460 RLREETERIV 470 TTYIREREGR 480 TKDQILLLID 490 IEQSYINTNH 500 EDFIGFANAQ 510 QRSTQLNKKR 520 AIPNQGEILV 530 IRRGWLTINN 540 ISLMKGGSKE 550 YWFVLTAESL 560 SWYKDEEEKE 570 KKYMLPLDNL 580 KIRDVEKGFM 590 SNKHVFAIFN 600 TEQRNVYKDL 610 RQIELACDSQ 620 EDVDSWKASF 630 LRAGVYPEKD 640 QAENEDGAQE 650 NTFSMDPQLE 660 RQVETIRNLV 670 DSYVAIINKS 680 IRDLMPKTIM 690 HLMINNTKAF 700 IHHELLAYLY 710 SSADQSSLME 720 ESADQAQRRD 730 DMLRMYHALK 740 EALNIIGDIS 750 TSTVSTPVPP 760 PVDDTWLQSA 770 SSHSPTPQRR 780 PVSSIHPPGR 790 PPAVRGPTPG 800 PPLIPVPVGA 810 AASFSAPPIP 820 SRPGPQSVFA 830 NSDLFPAPPQ 840 IPSRPVRIPP 850 GIPPGVPSRR 860 PPAAPSRPTI 870 IRPAEPSLLD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005814 centriole
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0030136 clathrin-coated vesicle
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030666 endocytic vesicle membrane
Cellular Component GO:0005768 endosome
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0030496 midbody
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0001891 phagocytic cup
Cellular Component GO:0030670 phagocytic vesicle membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0002102 podosome
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0045211 postsynaptic membrane
Cellular Component GO:0098793 presynapse
Cellular Component GO:0055037 recycling endosome
Cellular Component GO:0045202 synapse
Cellular Component GO:0001931 uropod
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Molecular Function GO:0017124 SH3 domain binding
Biological Process GO:0061572 actin filament bundle organization
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0006914 autophagy
Biological Process GO:0007098 centrosome cycle
Biological Process GO:0006897 endocytosis
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
Biological Process GO:0061024 membrane organization
Biological Process GO:0097749 membrane tubulation
Biological Process GO:1903526 negative regulation of membrane tubulation
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0006909 phagocytosis
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0006892 post-Golgi vesicle-mediated transport
Biological Process GO:0051258 protein polymerization
Biological Process GO:0031623 receptor internalization
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0030516 regulation of axon extension
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0007165 signal transduction
Biological Process GO:0043149 stress fiber assembly
Biological Process GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane
Biological Process GO:0048489 synaptic vesicle transport
Biological Process GO:0033572 transferrin transport
Biological Process GO:0099050 vesicle scission

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.