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Overview

Uniprot IDP50748
Protein NameKinetochore-associated protein 1
Gene NameKNTC1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
713 LALSDFEKENTTTIV

Function

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex

Protein Sequence

10 MWNDIELLTN 20 DDTGSGYLSV 30 GSRKEHGTAL 40 YQVDLLVKIS 50 SEKASLNPKI 60 QACSLSDGFI 70 IVADQSVILL 80 DSICRSLQLH 90 LVFDTEVDVV 100 GLCQEGKFLL 110 VGERSGNLHL 120 IHVTSKQTLL 130 TNAFVQKAND 140 ENRRTYQNLV 150 IEKDGSNEGT 160 YYMLLLTYSG 170 FFCITNLQLL 180 KIQQAIENVD 190 FSTAKKLQGQ 200 IKSSFISTEN 210 YHTLGCLSLV 220 AGDLASEVPV 230 IIGGTGNCAF 240 SKWEPDSSKK 250 GMTVKNLIDA 260 EIIKGAKKFQ 270 LIDNLLFVLD 280 TDNVLSLWDI 290 YTLTPVWNWP 300 SLHVEEFLLT 310 TEADSPSSVT 320 WQGITNLKLI 330 ALTASANKKM 340 KNLMVYSLPT 350 MEILYSLEVS 360 SVSSLVQTGI 370 STDTIYLLEG 380 VCKNDPKLSE 390 DSVSVLVLRC 400 LTEALPENRL 410 SRLLHKHRFA 420 EAESFAIQFG 430 LDVELVYKVK 440 SNHILEKLAL 450 SSVDASEQTE 460 WQQLVDDAKE 470 NLHKIQDDEF 480 VVNYCLKAQW 490 ITYETTQEML 500 NYAKTRLLKK 510 EDKTALIYSD 520 GLKEVLRAHA 530 KLTTFYGAFG 540 PEKFSGSSWI 550 EFLNNEDDLK 560 DIFLQLKEGN 570 LVCAQYLWLR 580 HRANFESRFD 590 VKMLESLLNS 600 MSASVSLQKL 610 CPWFKNDVIP 620 FVRRTVPEGQ 630 IILAKWLEQA 640 ARNLELTDKA 650 NWPENGLQLA 660 EIFFTAEKTD 670 ELGLASSWHW 680 ISLKDYQNTE 690 EVCQLRTLVN 700 NLRELITLHR 710 KYNCKLALSD 720 FEKENTTTIV 730 FRMFDKVLAP 740 ELIPSILEKF 750 IRVYMREHDL 760 QEEELLLLYI 770 EDLLNRCSSK 780 STSLFETAWE 790 AKAMAVIACL 800 SDTDLIFDAV 810 LKIMYAAVVP 820 WSAAVEQLVK 830 QHLEMDHPKV 840 KLLQESYKLM 850 EMKKLLRGYG 860 IREVNLLNKE 870 IMRVVRYILK 880 QDVPSSLEDA 890 LKVAQAFMLS 900 DDEIYSLRII 910 DLIDREQGED 920 CLLLLKSLPP 930 AEAEKTAERV 940 IIWARLALQE 950 EPDHSKEGKA 960 WRMSVAKTSV 970 DILKILCDIQ 980 KDNLQKKDEC 990 EEMLKLFKEV 1000 ASLQENFEVF 1010 LSFEDYSNSS 1020 LVADLREQHI 1030 KAHEVAQAKH 1040 KPGSTPEPIA 1050 AEVRSPSMES 1060 KLHRQALALQ 1070 MSKQELEAEL 1080 TLRALKDGNI 1090 KTALKKCSDL 1100 FKYHCNADTG 1110 KLLFLTCQKL 1120 CQMLADNVPV 1130 TVPVGLNLPS 1140 MIHDLASQAA 1150 TICSPDFLLD 1160 ALELCKHTLM 1170 AVELSRQCQM 1180 DDCGILMKAS 1190 FGTHKDPYEE 1200 WSYSDFFSED 1210 GIVLESQMVL 1220 PVIYELISSL 1230 VPLAESKRYP 1240 LESTSLPYCS 1250 LNEGDGLVLP 1260 VINSISALLQ 1270 NLQESSQWEL 1280 ALRFVVGSFG 1290 TCLQHSVSNF 1300 MNATLSEKLF 1310 GETTLVKSRH 1320 VVMELKEKAV 1330 IFIRENATTL 1340 LHKVFNCRLV 1350 DLDLALGYCT 1360 LLPQKDVFEN 1370 LWKLIDKAWQ 1380 NYDKILAISL 1390 VGSELASLYQ 1400 EIEMGLKFRE 1410 LSTDAQWGIR 1420 LGKLGISFQP 1430 VFRQHFLTKK 1440 DLIKALVENI 1450 DMDTSLILEY 1460 CSTFQLDCDA 1470 VLQLFIETLL 1480 HNTNAGQGQG 1490 DASMDSAKRR 1500 HPKLLAKALE 1510 MVPLLTSTKD 1520 LVISLSGILH 1530 KLDPYDYEMI 1540 EVVLKVIERA 1550 DEKITNININ 1560 QALSILKHLK 1570 SYRRISPPVD 1580 LEYQYMLEHV 1590 ITLPSAAQTR 1600 LPFHLIFFGT 1610 AQNFWKILST 1620 ELSEESFPTL 1630 LLISKLMKFS 1640 LDTLYVSTAK 1650 HVFEKKLKPK 1660 LLKLTQAKSS 1670 TLINKEITKI 1680 TQTIESCLLS 1690 IVNPEWAVAI 1700 AISLAQDIPE 1710 GSFKISALKF 1720 CLYLAERWLQ 1730 NIPSQDEKRE 1740 KAEALLKKLH 1750 IQYRRSGTEA 1760 VLIAHKLNTE 1770 EYLRVIGKPA 1780 HLIVSLYEHP 1790 SINQRIQNSS 1800 GTDYPDIHAA 1810 AKEIAEVNEI 1820 NLEKVWDMLL 1830 EKWLCPSTKP 1840 GEKPSELFEL 1850 QEDEALRRVQ 1860 YLLLSRPIDY 1870 SSRMLFVFAT 1880 STTTTLGMHQ 1890 LTFAHRTRAL 1900 QCLFYLADKE 1910 TIESLFKKPI 1920 EEVKSYLRCI 1930 TFLASFETLN 1940 IPITYELFCS 1950 SPKEGMIKGL 1960 WKNHSHESMA 1970 VRLVTELCLE 1980 YKIYDLQLWN 1990 GLLQKLLGFN 2000 MIPYLRKVLK 2010 AISSIHSLWQ 2020 VPYFSKAWQR 2030 VIQIPLLSAS 2040 CPLSPDQLSD 2050 CSESLIAVLE 2060 CPVSGDLDLI 2070 GVARQYIQLE 2080 LPAFALACLM 2090 LMPHSEKRHQ 2100 QIKNFLGSCD 2110 PQVILKQLEE 2120 HMNTGQLAGF 2130 SHQIRSLILN 2140 NIINKKEFGI 2150 LAKTKYFQML 2160 KMHAMNTNNI 2170 TELVNYLAND 2180 LSLDEASVLI 2190 TEYSKHCGKP 2200 VPPDTAPCEI LKMFLSGLS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005828 kinetochore microtubule
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990423 RZZ complex
Cellular Component GO:0000922 spindle pole
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0051301 cell division
Biological Process GO:0000070 mitotic sister chromatid segregation
Biological Process GO:0007094 mitotic spindle assembly checkpoint signaling
Biological Process GO:1903394 protein localization to kinetochore involved in kinetochore assembly
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0051988 regulation of attachment of spindle microtubules to kinetochore
Biological Process GO:0007096 regulation of exit from mitosis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.