Search Results
Overview
| Uniprot ID | P50752 |
|---|---|
| Protein Name | Troponin T, cardiac muscle |
| Gene Name | Tnnt2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 127 | EAHFENRKKEEEELI |
| 137 | EEELISLKDRIEKRR |
| 230 | KILAERRKALAIDHL |
| 247 | DQLREKAKELWQSIH |
| 76 | EGPVEDTKPKPSRLF |
| 78 | PVEDTKPKPSRLFMP |
Function
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity
Protein Sequence
10
MSDAEEVVEE
20
YEEEQEEEDW
30
SEEEEDEQEE
40
AVEEEEAGGA
50
EPEPEGEAET
60
EEANVEEVGP
70
DEEAKDAEEG
80
PVEDTKPKPS
90
RLFMPNLVPP
100
KIPDGERVDF
110
DDIHRKRVEK
120
DLNELQTLIE
130
AHFENRKKEE
140
EELISLKDRI
150
EKRRAERAEQ
160
QRIRNEREKE
170
RQNRLAEERA
180
RREEEENRRK
190
AEDEARKKKA
200
LSNMMHFGGY
210
IQKQAQTERK
220
SGKRQTEREK
230
KKKILAERRK
240
ALAIDHLNED
250
QLREKAKELW
260
QSIHNLEAEK
270
FDLQEKFKQQ
280
KYEINVLRNR
290
INDNQKVSKT
300
RGKAKVTGRW
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097512 | cardiac myofibril |
| Cellular Component | GO:1990584 | cardiac Troponin complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030016 | myofibril |
| Cellular Component | GO:0030017 | sarcomere |
| Cellular Component | GO:0005865 | striated muscle thin filament |
| Cellular Component | GO:0005861 | troponin complex |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Molecular Function | GO:0005523 | tropomyosin binding |
| Molecular Function | GO:0030172 | troponin C binding |
| Molecular Function | GO:0031013 | troponin I binding |
| Biological Process | GO:0051764 | actin crosslink formation |
| Biological Process | GO:0055009 | atrial cardiac muscle tissue morphogenesis |
| Biological Process | GO:0060048 | cardiac muscle contraction |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0006936 | muscle contraction |
| Biological Process | GO:0030049 | muscle filament sliding |
| Biological Process | GO:0032780 | negative regulation of ATP-dependent activity |
| Biological Process | GO:0032781 | positive regulation of ATP-dependent activity |
| Biological Process | GO:0008016 | regulation of heart contraction |
| Biological Process | GO:0032972 | regulation of muscle filament sliding speed |
| Biological Process | GO:0009617 | response to bacterium |
| Biological Process | GO:0051592 | response to calcium ion |
| Biological Process | GO:0045214 | sarcomere organization |
| Biological Process | GO:0055010 | ventricular cardiac muscle tissue morphogenesis |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.