Search Results
Overview
| Uniprot ID | P50993 |
|---|---|
| Protein Name | Sodium/potassium-transporting ATPase subunit alpha-2 |
| Gene Name | ATP1A2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 485 | IPFNSTNKYQLSIHE |
| 52 | SLDELGRKYQVDLSK |
| 523 | STILVQGKEIPLDKE |
| 59 | KYQVDLSKGLTNQRA |
Function
Catalytic subunit of the Na(+)/K(+)-ATPase that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle (PubMed:33880529). It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function (PubMed:33880529)
Protein Sequence
10
MGRGAGREYS
20
PAATTAENGG
30
GKKKQKEKEL
40
DELKKEVAMD
50
DHKLSLDELG
60
RKYQVDLSKG
70
LTNQRAQDVL
80
ARDGPNALTP
90
PPTTPEWVKF
100
CRQLFGGFSI
110
LLWIGAILCF
120
LAYGIQAAME
130
DEPSNDNLYL
140
GVVLAAVVIV
150
TGCFSYYQEA
160
KSSKIMDSFK
170
NMVPQQALVI
180
REGEKMQINA
190
EEVVVGDLVE
200
VKGGDRVPAD
210
LRIISSHGCK
220
VDNSSLTGES
230
EPQTRSPEFT
240
HENPLETRNI
250
CFFSTNCVEG
260
TARGIVIATG
270
DRTVMGRIAT
280
LASGLEVGRT
290
PIAMEIEHFI
300
QLITGVAVFL
310
GVSFFVLSLI
320
LGYSWLEAVI
330
FLIGIIVANV
340
PEGLLATVTV
350
CLTLTAKRMA
360
RKNCLVKNLE
370
AVETLGSTST
380
ICSDKTGTLT
390
QNRMTVAHMW
400
FDNQIHEADT
410
TEDQSGATFD
420
KRSPTWTALS
430
RIAGLCNRAV
440
FKAGQENISV
450
SKRDTAGDAS
460
ESALLKCIEL
470
SCGSVRKMRD
480
RNPKVAEIPF
490
NSTNKYQLSI
500
HEREDSPQSH
510
VLVMKGAPER
520
ILDRCSTILV
530
QGKEIPLDKE
540
MQDAFQNAYM
550
ELGGLGERVL
560
GFCQLNLPSG
570
KFPRGFKFDT
580
DELNFPTEKL
590
CFVGLMSMID
600
PPRAAVPDAV
610
GKCRSAGIKV
620
IMVTGDHPIT
630
AKAIAKGVGI
640
ISEGNETVED
650
IAARLNIPMS
660
QVNPREAKAC
670
VVHGSDLKDM
680
TSEQLDEILK
690
NHTEIVFART
700
SPQQKLIIVE
710
GCQRQGAIVA
720
VTGDGVNDSP
730
ALKKADIGIA
740
MGISGSDVSK
750
QAADMILLDD
760
NFASIVTGVE
770
EGRLIFDNLK
780
KSIAYTLTSN
790
IPEITPFLLF
800
IIANIPLPLG
810
TVTILCIDLG
820
TDMVPAISLA
830
YEAAESDIMK
840
RQPRNSQTDK
850
LVNERLISMA
860
YGQIGMIQAL
870
GGFFTYFVIL
880
AENGFLPSRL
890
LGIRLDWDDR
900
TMNDLEDSYG
910
QEWTYEQRKV
920
VEFTCHTAFF
930
ASIVVVQWAD
940
LIICKTRRNS
950
VFQQGMKNKI
960
LIFGLLEETA
970
LAAFLSYCPG
980
MGVALRMYPL
990
KVTWWFCAFP
1000
YSLLIFIYDE
1010
VRKLILRRYP
1020
GGWVEKETYY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0009986 | cell surface |
| Biological Process | GO:0035725 | sodium ion transmembrane transport |
| Biological Process | GO:0006814 | sodium ion transport |
| Biological Process | GO:0150104 | transport across blood-brain barrier |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:1903561 | extracellular vesicle |
| Cellular Component | GO:0014704 | intercalated disc |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0031090 | organelle membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0005890 | sodium:potassium-exchanging ATPase complex |
| Cellular Component | GO:0030315 | T-tubule |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0019829 | ATPase-coupled monoatomic cation transmembrane transporter activity |
| Molecular Function | GO:0005391 | P-type sodium:potassium-exchanging transporter activity |
| Molecular Function | GO:0016791 | phosphatase activity |
| Molecular Function | GO:0030955 | potassium ion binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0031402 | sodium ion binding |
| Molecular Function | GO:0005496 | steroid binding |
| Molecular Function | GO:1990239 | steroid hormone binding |
| Biological Process | GO:0021764 | amygdala development |
| Biological Process | GO:0046034 | ATP metabolic process |
| Biological Process | GO:0001662 | behavioral fear response |
| Biological Process | GO:0060048 | cardiac muscle contraction |
| Biological Process | GO:0086064 | cell communication by electrical coupling involved in cardiac conduction |
| Biological Process | GO:0071260 | cellular response to mechanical stimulus |
| Biological Process | GO:0071383 | cellular response to steroid hormone stimulus |
| Biological Process | GO:0030007 | intracellular potassium ion homeostasis |
| Biological Process | GO:0006883 | intracellular sodium ion homeostasis |
| Biological Process | GO:0040011 | locomotion |
| Biological Process | GO:0035641 | locomotory exploration behavior |
| Biological Process | GO:0086012 | membrane depolarization during cardiac muscle cell action potential |
| Biological Process | GO:0086009 | membrane repolarization |
| Biological Process | GO:0098655 | monoatomic cation transmembrane transport |
| Biological Process | GO:1903170 | negative regulation of calcium ion transmembrane transport |
| Biological Process | GO:0051481 | negative regulation of cytosolic calcium ion concentration |
| Biological Process | GO:0045822 | negative regulation of heart contraction |
| Biological Process | GO:0001504 | neurotransmitter uptake |
| Biological Process | GO:0021989 | olfactory cortex development |
| Biological Process | GO:0045823 | positive regulation of heart contraction |
| Biological Process | GO:1990573 | potassium ion import across plasma membrane |
| Biological Process | GO:0071805 | potassium ion transmembrane transport |
| Biological Process | GO:0006813 | potassium ion transport |
| Biological Process | GO:1902600 | proton transmembrane transport |
| Biological Process | GO:0086004 | regulation of cardiac muscle cell contraction |
| Biological Process | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| Biological Process | GO:0051946 | regulation of glutamate uptake involved in transmission of nerve impulse |
| Biological Process | GO:0006937 | regulation of muscle contraction |
| Biological Process | GO:0002087 | regulation of respiratory gaseous exchange by nervous system process |
| Biological Process | GO:0006942 | regulation of striated muscle contraction |
| Biological Process | GO:0051966 | regulation of synaptic transmission, glutamatergic |
| Biological Process | GO:0002026 | regulation of the force of heart contraction |
| Biological Process | GO:0055119 | relaxation of cardiac muscle |
| Biological Process | GO:0010996 | response to auditory stimulus |
| Biological Process | GO:1903416 | response to glycoside |
| Biological Process | GO:0035094 | response to nicotine |
| Biological Process | GO:0036376 | sodium ion export across plasma membrane |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.