Search Results
Overview
| Uniprot ID | P51114 |
|---|---|
| Protein Name | RNA-binding protein FXR1 |
| Gene Name | FXR1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 325 | IEGDNENKLPREDGM |
Function
mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Biological Process | GO:1900272 | negative regulation of long-term synaptic potentiation |
| Biological Process | GO:1902373 | negative regulation of mRNA catabolic process |
| Biological Process | GO:0017148 | negative regulation of translation |
| Biological Process | GO:0032720 | negative regulation of tumor necrosis factor production |
| Biological Process | GO:0051292 | nuclear pore complex assembly |
| Biological Process | GO:0051664 | nuclear pore localization |
| Biological Process | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity |
| Biological Process | GO:2000637 | positive regulation of miRNA-mediated gene silencing |
| Biological Process | GO:0035025 | positive regulation of Rho protein signal transduction |
| Biological Process | GO:0045727 | positive regulation of translation |
| Biological Process | GO:0045187 | regulation of circadian sleep/wake cycle, sleep |
| Biological Process | GO:1903311 | regulation of mRNA metabolic process |
| Biological Process | GO:0043488 | regulation of mRNA stability |
| Biological Process | GO:0050767 | regulation of neurogenesis |
| Biological Process | GO:0051966 | regulation of synaptic transmission, glutamatergic |
| Biological Process | GO:0099577 | regulation of translation at presynapse, modulating synaptic transmission |
| Biological Process | GO:0060538 | skeletal muscle organ development |
| Biological Process | GO:0007286 | spermatid development |
| Cellular Component | GO:0043034 | costamere |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0043232 | intracellular membraneless organelle |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0005840 | ribosome |
| Molecular Function | GO:0140693 | molecular condensate scaffold activity |
| Molecular Function | GO:0035925 | mRNA 3'-UTR AU-rich region binding |
| Molecular Function | GO:0003730 | mRNA 3'-UTR binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0043021 | ribonucleoprotein complex binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0033592 | RNA strand annealing activity |
| Molecular Function | GO:0045182 | translation regulator activity |
| Biological Process | GO:0048513 | animal organ development |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0021542 | dentate gyrus development |
| Biological Process | GO:0140694 | membraneless organelle assembly |
| Biological Process | GO:0061157 | mRNA destabilization |
| Biological Process | GO:0051028 | mRNA transport |
| Biological Process | GO:0007517 | muscle organ development |
| Biological Process | GO:0050728 | negative regulation of inflammatory response |
Reference
[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.