Search Results
Overview
| Uniprot ID | P51145 |
|---|---|
| Protein Name | Fos-related antigen 2 |
| Gene Name | Fosl2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | LPRPGVIKTIGTTVG |
Function
Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (PubMed:15299028)
Protein Sequence
10
MYQDYPGNFD
20
TSSRGSSGSP
30
AHAESYSSGG
40
GGQQKFRVDM
50
PGSGSAFIPT
60
INAITTSQDL
70
QWMVQPTVIT
80
SMSNPYPRSH
90
PYSPLPGLAS
100
VPGHMALPRP
110
GVIKTIGTTV
120
GRRRRDEQLS
130
PEEEEKRRIR
140
RERNKLAAAK
150
CRNRRRELTE
160
KLQAETEELE
170
EEKSGLQKEI
180
AELQKEKEKL
190
EFMLVAHGPV
200
CKISPEERRS
210
PPTSGLQSLR
220
GTGSAVGPVV
230
VKQEPPEEDS
240
PSSSAGMDKT
250
QRSVIKPISI
260
AGGGFYGEEP
270
LHTPIVVTST
280
PAITPGTSNL
290
VFTYPSVLEQ
300
ESPASPSESC
310
SKAHRRSSSS
320
GDQSSDSLNS
PTLLAL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0002437 | inflammatory response to antigenic stimulus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Cellular Component | GO:0035976 | transcription factor AP-1 complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Biological Process | GO:0061144 | alveolar secondary septum development |
| Biological Process | GO:0030183 | B cell differentiation |
| Biological Process | GO:0042100 | B cell proliferation |
| Biological Process | GO:0060348 | bone development |
| Biological Process | GO:0030282 | bone mineralization |
| Biological Process | GO:0051216 | cartilage development |
| Biological Process | GO:0000902 | cell morphogenesis |
| Biological Process | GO:0002062 | chondrocyte differentiation |
| Biological Process | GO:0035988 | chondrocyte proliferation |
| Biological Process | GO:0007623 | circadian rhythm |
| Biological Process | GO:0032964 | collagen biosynthetic process |
| Biological Process | GO:0032963 | collagen metabolic process |
| Biological Process | GO:0001661 | conditioned taste aversion |
| Biological Process | GO:1904606 | fat cell apoptotic process |
| Biological Process | GO:0045444 | fat cell differentiation |
| Biological Process | GO:0060613 | fat pad development |
| Biological Process | GO:0007565 | female pregnancy |
| Biological Process | GO:0010467 | gene expression |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0003417 | growth plate cartilage development |
| Biological Process | GO:0048872 | homeostasis of number of cells |
| Biological Process | GO:0048873 | homeostasis of number of cells within a tissue |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:1901142 | insulin metabolic process |
| Biological Process | GO:0003334 | keratinocyte development |
| Biological Process | GO:0048286 | lung alveolus development |
| Biological Process | GO:0060427 | lung connective tissue development |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0030225 | macrophage differentiation |
| Biological Process | GO:0070254 | mucus secretion |
| Biological Process | GO:0035264 | multicellular organism growth |
| Biological Process | GO:0036446 | myofibroblast differentiation |
| Biological Process | GO:0030223 | neutrophil differentiation |
| Biological Process | GO:0001865 | NK T cell differentiation |
| Biological Process | GO:0001503 | ossification |
| Biological Process | GO:0001649 | osteoblast differentiation |
| Biological Process | GO:0030316 | osteoclast differentiation |
| Biological Process | GO:0009648 | photoperiodism |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0048146 | positive regulation of fibroblast proliferation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0040014 | regulation of multicellular organism growth |
| Biological Process | GO:1904760 | regulation of myofibroblast differentiation |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:1904975 | response to bleomycin |
| Biological Process | GO:0051591 | response to cAMP |
| Biological Process | GO:0034097 | response to cytokine |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:1904321 | response to forskolin |
| Biological Process | GO:0051384 | response to glucocorticoid |
| Biological Process | GO:0140459 | response to Gram-positive bacterium |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0035902 | response to immobilization stress |
| Biological Process | GO:0035962 | response to interleukin-13 |
| Biological Process | GO:0098760 | response to interleukin-7 |
| Biological Process | GO:1990823 | response to leukemia inhibitory factor |
| Biological Process | GO:0009416 | response to light stimulus |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0009612 | response to mechanical stimulus |
| Biological Process | GO:0043434 | response to peptide hormone |
| Biological Process | GO:0032570 | response to progesterone |
| Biological Process | GO:0009636 | response to toxic substance |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0048745 | smooth muscle tissue development |
| Biological Process | GO:0030217 | T cell differentiation |
| Biological Process | GO:0050852 | T cell receptor signaling pathway |
| Biological Process | GO:0048771 | tissue remodeling |
| Biological Process | GO:0006366 | transcription by RNA polymerase II |
| Biological Process | GO:0032905 | transforming growth factor beta1 production |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.