Search Results
Overview
| Uniprot ID | P51452 |
|---|---|
| Protein Name | Dual specificity protein phosphatase 3 |
| Gene Name | DUSP3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 116 | IDQALAQKNGRVLVH |
| 50 | SVAQDIPKLQKLGIT |
| 53 | QDIPKLQKLGITHVL |
Function
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines (PubMed:10224087, PubMed:11863439). Specifically dephosphorylates and inactivates ERK1 and ERK2 (PubMed:10224087, PubMed:11863439)
Protein Sequence
10
MSGSFELSVQ
20
DLNDLLSDGS
30
GCYSLPSQPC
40
NEVTPRIYVG
50
NASVAQDIPK
60
LQKLGITHVL
70
NAAEGRSFMH
80
VNTNANFYKD
90
SGITYLGIKA
100
NDTQEFNLSA
110
YFERAADFID
120
QALAQKNGRV
130
LVHCREGYSR
140
SPTLVIAYLM
150
MRQKMDVKSA
160
LSIVRQNREI
170
GPNDGFLAQL
180
CQLNDRLAKE
GKLKP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0001772 | immunological synapse |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0008092 | cytoskeletal protein binding |
| Molecular Function | GO:0033549 | MAP kinase phosphatase activity |
| Molecular Function | GO:0016791 | phosphatase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Molecular Function | GO:1990782 | protein tyrosine kinase binding |
| Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
| Molecular Function | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
| Molecular Function | GO:0030294 | receptor signaling protein tyrosine kinase inhibitor activity |
| Molecular Function | GO:0030971 | receptor tyrosine kinase binding |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0016311 | dephosphorylation |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:0050922 | negative regulation of chemotaxis |
| Biological Process | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0046329 | negative regulation of JNK cascade |
| Biological Process | GO:0043409 | negative regulation of MAPK cascade |
| Biological Process | GO:0050868 | negative regulation of T cell activation |
| Biological Process | GO:0050860 | negative regulation of T cell receptor signaling pathway |
| Biological Process | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| Biological Process | GO:0120183 | positive regulation of focal adhesion disassembly |
| Biological Process | GO:0045931 | positive regulation of mitotic cell cycle |
| Biological Process | GO:0051893 | regulation of focal adhesion assembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.