Search Results
Overview
| Uniprot ID | P51553 |
|---|---|
| Protein Name | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial |
| Gene Name | IDH3G |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 159 | PGVVTRHKDIDILIV |
| 190 | AGVVESLKIITKAKS |
Function
Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers
Protein Sequence
10
MALKVATVAG
20
SAAKAVLGPA
30
LLCRPWEVLG
40
AHEVPSRNIF
50
SEQTIPPSAK
60
YGGRHTVTMI
70
PGDGIGPELM
80
LHVKSVFRHA
90
CVPVDFEEVH
100
VSSNADEEDI
110
RNAIMAIRRN
120
RVALKGNIET
130
NHNLPPSHKS
140
RNNILRTSLD
150
LYANVIHCKS
160
LPGVVTRHKD
170
IDILIVRENT
180
EGEYSSLEHE
190
SVAGVVESLK
200
IITKAKSLRI
210
AEYAFKLAQE
220
SGRKKVTAVH
230
KANIMKLGDG
240
LFLQCCREVA
250
ARYPQITFEN
260
MIVDNTTMQL
270
VSRPQQFDVM
280
VMPNLYGNIV
290
NNVCAGLVGG
300
PGLVAGANYG
310
HVYAVFETAT
320
RNTGKSIANK
330
NIANPTATLL
340
ASCMMLDHLK
350
LHSYATSIRK
360
AVLASMDNEN
370
MHTPDIGGQG
380
TTSEAIQDVI
390
RHIRVINGRA
VEA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0045242 | isocitrate dehydrogenase complex (NAD+) |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0001917 | photoreceptor inner segment |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004449 | isocitrate dehydrogenase (NAD+) activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0051287 | NAD binding |
| Biological Process | GO:0005975 | carbohydrate metabolic process |
| Biological Process | GO:0006102 | isocitrate metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.