Search Results
Overview
| Uniprot ID | P51570 |
|---|---|
| Protein Name | Galactokinase |
| Gene Name | GALK1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 252 | EVARALGKESLREVQ |
| 272 | AARDLVSKEGFRRAR |
| 69 | VLVGSPRKDGLVSLL |
Function
Catalyzes the transfer of a phosphate from ATP to alpha-D-galactose and participates in the first committed step in the catabolism of galactose
Protein Sequence
10
MAALRQPQVA
20
ELLAEARRAF
30
REEFGAEPEL
40
AVSAPGRVNL
50
IGEHTDYNQG
60
LVLPMALELM
70
TVLVGSPRKD
80
GLVSLLTTSE
90
GADEPQRLQF
100
PLPTAQRSLE
110
PGTPRWANYV
120
KGVIQYYPAA
130
PLPGFSAVVV
140
SSVPLGGGLS
150
SSASLEVATY
160
TFLQQLCPDS
170
GTIAARAQVC
180
QQAEHSFAGM
190
PCGIMDQFIS
200
LMGQKGHALL
210
IDCRSLETSL
220
VPLSDPKLAV
230
LITNSNVRHS
240
LASSEYPVRR
250
RQCEEVARAL
260
GKESLREVQL
270
EELEAARDLV
280
SKEGFRRARH
290
VVGEIRRTAQ
300
AAAALRRGDY
310
RAFGRLMVES
320
HRSLRDDYEV
330
SCPELDQLVE
340
AALAVPGVYG
350
SRMTGGGFGG
360
CTVTLLEASA
370
APHAMRHIQE
380
HYGGTATFYL
390
SQAADGAKVL
CL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004335 | galactokinase activity |
| Molecular Function | GO:0005534 | galactose binding |
| Biological Process | GO:0033499 | galactose catabolic process via UDP-galactose, Leloir pathway |
| Biological Process | GO:0006012 | galactose metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.