Search Results
Overview
| Uniprot ID | P51580 |
|---|---|
| Protein Name | Thiopurine S-methyltransferase |
| Gene Name | TPMT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 37 | QDKWVNGKTAFHQEQ |
| 50 | EQGHQLLKKHLDTFL |
| 51 | QGHQLLKKHLDTFLK |
Function
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:18484748, PubMed:657528). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified
Protein Sequence
10
MDGTRTSLDI
20
EEYSDTEVQK
30
NQVLTLEEWQ
40
DKWVNGKTAF
50
HQEQGHQLLK
60
KHLDTFLKGK
70
SGLRVFFPLC
80
GKAVEMKWFA
90
DRGHSVVGVE
100
ISELGIQEFF
110
TEQNLSYSEE
120
PITEIPGTKV
130
FKSSSGNISL
140
YCCSIFDLPR
150
TNIGKFDMIW
160
DRGALVAINP
170
GDRKCYADTM
180
FSLLGKKFQY
190
LLCVLSYDPT
200
KHPGPPFYVP
210
HAEIERLFGK
220
ICNIRCLEKV
230
DAFEERHKSW
240
GIDCLFEKLY
LLTEK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:1904047 | S-adenosyl-L-methionine binding |
| Molecular Function | GO:0008119 | thiopurine S-methyltransferase activity |
| Biological Process | GO:0032259 | methylation |
| Biological Process | GO:0006139 | nucleobase-containing compound metabolic process |
| Biological Process | GO:0042178 | xenobiotic catabolic process |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.